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Examining the Genetic Predictors of Coronary Artery Calcification in African Americans

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00925561
Recruitment Status : Completed
First Posted : June 22, 2009
Last Update Posted : June 19, 2013
National Heart, Lung, and Blood Institute (NHLBI)
University of Mississippi Medical Center
Wake Forest University
Mayo Clinic
Information provided by (Responsible Party):
Patricia Peyser, University of Michigan

Brief Summary:
Coronary artery disease (CAD) is an important health concern for African Americans, who are diagnosed with CAD at high rates. Coronary artery calcification, which is characterized by calcium deposits in the coronary arteries, is a contributing factor to CAD. This study will examine the possible genetic causes of coronary artery calcification in African Americans.

Condition or disease

Detailed Description:

In the United States, more people die from CAD than any other disease, with African Americans, particularly women and young men, being more affected by CAD than European Americans. One cause of CAD is atherosclerosis, a condition in which deposits of fat, cholesterol, and other substances build up along the inner walls of arteries. Coronary artery calcification occurs as a result of atherosclerosis and is characterized by calcium build up in the arteries. Non-invasive imaging, including computed tomography (CT) scans, of coronary artery calcification is an effective way to assess CAD risk. The Genetic Epidemiology Network of Arteriopathy (GENOA) study, which is part of the Family Blood Pressure Program (FBPP), is a study that examined siblings with high blood pressure during two exams conducted between 1995 and 2004. The purpose of this new GENOA study, which will enroll past GENOA participants, is to identify genetic factors that may lead to the development of coronary artery calcification in African Americans. Conducting genetic studies in the African American population will result in greater understanding of the mechanisms of atherosclerosis, and may lead to improved strategies for the early identification of people at risk for CAD and the development of new treatments for CAD.

This study will enroll people who have participated in the second GENOA exam and who live in Jackson, Mississippi. Participants will attend one study visit at the University of Mississippi Medical Center. During the study visit, participants will be interviewed by study staff about their medical and family health history; health behaviors; physical activity levels; and use of tobacco, alcohol, and medications. They will complete a walking activity and tasks to assess memory, thinking speed, and accuracy. Participants will also complete a questionnaire about their mood, a physical examination, a CT scan of the heart, and a blood collection. A portion of blood will be stored for future research studies.

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Study Type : Observational
Actual Enrollment : 752 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Predictors of Coronary Artery Calcification in an African American Cohort
Study Start Date : January 2009
Actual Primary Completion Date : April 2013
Actual Study Completion Date : April 2013

Resource links provided by the National Library of Medicine

No treatment

Primary Outcome Measures :
  1. Coronary Artery Calcification [ Time Frame: Measured during participants' single study visit ]

Biospecimen Retention:   Samples With DNA
Blood to measure risk factors and stored DNA for genetic studies

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study population will come from Jackson, MS and will include all men and women belonging to sibships that previously participated in the second GENOA exam. The sampling frame includes 1482 African Americans in 627 sibships providing 1552 sibling pairs from Jackson, Mississippi.

Inclusion Criteria:

  • Participated in the second GENOA exam in Jackson, Mississippi and is alive and willing to participate

Exclusion Criteria:

  • Reported a history of heart attack, stroke, or coronary or non-coronary heart surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00925561

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United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Sponsors and Collaborators
University of Michigan
National Heart, Lung, and Blood Institute (NHLBI)
University of Mississippi Medical Center
Wake Forest University
Mayo Clinic
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Principal Investigator: Patricia Peyser, Ph.D. University of Michigan

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Responsible Party: Patricia Peyser, Professor of Epidemiology, University of Michigan Identifier: NCT00925561     History of Changes
Other Study ID Numbers: 643
R01HL085571 ( U.S. NIH Grant/Contract )
5R01HL085571 ( U.S. NIH Grant/Contract )
First Posted: June 22, 2009    Key Record Dates
Last Update Posted: June 19, 2013
Last Verified: June 2013

Keywords provided by Patricia Peyser, University of Michigan:
Coronary Artery Calcification

Additional relevant MeSH terms:
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Coronary Artery Disease
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Calcium Metabolism Disorders
Metabolic Diseases
Coronary Disease
Myocardial Ischemia
Heart Diseases