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Cetuximab and Trastuzumab in Treating Patients With Metastatic Pancreatic Cancer That Progressed After Previous Treatment With Gemcitabine (THERAPY)

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ClinicalTrials.gov Identifier: NCT00923299
Recruitment Status : Completed
First Posted : June 18, 2009
Last Update Posted : April 16, 2019
Sponsor:
Information provided by (Responsible Party):
Institut du Cancer de Montpellier - Val d'Aurelle

Brief Summary:

RATIONALE: Monoclonal antibodies, such as cetuximab and trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving cetuximab together with trastuzumab may kill more tumor cells.

PURPOSE: This phase I/II trial is studying the side effects and best dose of trastuzumab when given together with cetuximab and to see how well it works in treating patients with metastatic pancreatic cancer that progressed after previous treatment with gemcitabine.


Condition or disease Intervention/treatment Phase
Pancreatic Cancer Drug: cetuximab Drug: trastuzumab Phase 1 Phase 2

Detailed Description:

OBJECTIVES:

Primary

  • Determine the recommended dose of trastuzumab when given with cetuximab in patients with metastatic pancreatic cancer that progressed after gemcitabine-based chemotherapy. (Phase I)
  • Evaluate the objective response rate as assessed by RECIST criteria. (Phase II)

Secondary

  • Evaluate the safety profile as assessed by NCI CTCAE v3.0.
  • Evaluate progression-free survival.
  • Evaluate overall survival.

OUTLINE: This is a multicenter, phase I dose-escalation study of trastuzumab followed by a phase II study.

Patients receive cetuximab IV over 1-2 hours and trastuzumab IV over 30-90 minutes on day 1. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months.


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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 33 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase I-II Study Evaluating Combined Treatment of Cetuximab and Trastuzumab in Metastatic Pancreatic Cancer Patients Progressing After Gemcitabine Based Chemotherapy.(THERAPY)
Study Start Date : December 2008
Actual Primary Completion Date : April 2010
Actual Study Completion Date : March 2011

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
cetuximab, trastuzumab Drug: cetuximab
Cetuximab at the initial dose of 400 mg/m² (J1S1) as a 2-hour infusion and then at the 250 mg/m² dose as a 1-hour infusion in subsequent weeks.

Drug: trastuzumab

Two dose levels of trastuzumab will be evaluated for Phase 1:

  • Level 1: a loading dose of 3 mg/kg as a 90-minute intravenous infusion at J1S1 and then 1.5 mg/kg as a 30-minute intravenous infusion for all subsequent weekly administrations;
  • Level 2: a loading dose of 4 mg/kg as a 90-minute intravenous infusion at J1S1 and then 2 mg/kg as a 30-minute intravenous infusion for all subsequent weekly administrations.




Primary Outcome Measures :
  1. Recommended dose of trastuzumab when given with cetuximab (Phase I) [ Time Frame: 15 days ]
    From baseline to the end of treatment

  2. Objective response rate as assessed by RECIST criteria (Phase II) [ Time Frame: Approximately 8 weeks ]
    From baseline to the end of treatment


Secondary Outcome Measures :
  1. Progression-free survival [ Time Frame: Approximately 36 months ]
    From baseline to the end of study

  2. Overall survival [ Time Frame: Approximately 36 months ]
    From baseline to the end of study



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed metastatic adenocarcinoma of the pancreas

    • Progressed after first-line or adjuvant gemcitabine-based chemotherapy
  • Measurable disease as assessed by RECIST criteria
  • No known brain metastasis or symptomatic carcinomatous leptomeningitis

PATIENT CHARACTERISTICS:

  • WHO performance status 0-1
  • Life expectancy ≥ 3 months
  • ANC ≥ 1,500/mm^3
  • Platelet count ≥ 100,000/mm^3
  • Hemoglobin ≥ 9 g/dL
  • Creatinine ≤ 1.5 times upper limit of normal (ULN)
  • Total bilirubin ≤ 2.5 times ULN
  • ALT/AST ≤ 5 times ULN
  • LVEF ≥ 55%
  • Not pregnant or nursing
  • Fertile patients must use effective contraception
  • No significant comorbidities, including any of the following:

    • Cardiovascular disease
    • Documented history of congestive heart failure
    • Uncontrolled, high-risk arrhythmia
    • Angina pectoris requiring treatment
    • Clinically significant valvular disease
    • Evidence of transmural myocardial infarction by ECG
    • Uncontrolled hypertension
    • Active bleeding
    • Clinically significant active infection
    • Severe dyspnea at rest
    • Oxygen-dependency
  • No other malignancy except basal cell carcinoma of the skin
  • No severe hypersensitivity to cetuximab or trastuzumab
  • No medical or psychological condition that would preclude study completion or giving informed consent
  • No legal incapacity or limited legal capacity

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • No prior cetuximab or trastuzumab
  • No other concurrent experimental drugs or anticancer therapy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00923299


Locations
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France
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
Montpellier, France, 34298
Sponsors and Collaborators
Institut du Cancer de Montpellier - Val d'Aurelle
Investigators
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Principal Investigator: Marc Ychou, MD, PhD Institut du Cancer de Montpellier - Val d'Aurelle

Publications of Results:
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Responsible Party: Institut du Cancer de Montpellier - Val d'Aurelle
ClinicalTrials.gov Identifier: NCT00923299     History of Changes
Other Study ID Numbers: CDR0000636018
CLCC-THERAPY
RECF0910
VA-2008/34
EUDRACT-2008-003988-39
First Posted: June 18, 2009    Key Record Dates
Last Update Posted: April 16, 2019
Last Verified: August 2017
Keywords provided by Institut du Cancer de Montpellier - Val d'Aurelle:
stage IV pancreatic cancer
recurrent pancreatic cancer
adenocarcinoma of the pancreas
Additional relevant MeSH terms:
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Pancreatic Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Endocrine Gland Neoplasms
Pancreatic Diseases
Digestive System Diseases
Endocrine System Diseases
Gemcitabine
Trastuzumab
Cetuximab
Antimetabolites, Antineoplastic
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents
Enzyme Inhibitors
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antineoplastic Agents, Immunological