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Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00919750
Recruitment Status : Completed
First Posted : June 12, 2009
Last Update Posted : July 16, 2018
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group

Study Description
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Brief Summary:
The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Condition or disease Intervention/treatment
Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Cerebral Anaplastic Astrocytoma Childhood Cerebral Astrocytoma Childhood Choroid Plexus Neoplasm Childhood Craniopharyngioma Childhood Grade I Meningioma Childhood Grade II Meningioma Childhood Grade III Meningioma Childhood Infratentorial Ependymoma Childhood Oligodendroglioma Childhood Supratentorial Ependymoma Ependymoma Newly Diagnosed Childhood Ependymoma Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood Cerebral Astrocytoma Recurrent Childhood Ependymoma Recurrent Childhood Medulloblastoma Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified Recurrent Childhood Visual Pathway Glioma Other: Cytology Specimen Collection Procedure

Detailed Description:

OBJECTIVES:

I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions.

II. Provide a repository for long-term storage of specimens from these patients.

III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study.

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Study Design
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Study Type : Observational
Actual Enrollment : 1258 participants
Official Title: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
Actual Study Start Date : February 16, 2004
Actual Primary Completion Date : June 30, 2018
Actual Study Completion Date : June 30, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Brain Tumors

Groups and Cohorts
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Group/Cohort Intervention/treatment
Ancillary-Correlative (tissue and blood sample collection)
Brain tumor tissue and blood specimens are collected from patients and banked for future study.
 Other: Cytology Specimen Collection Procedure
Correlative studies
Other Name: Cytologic Sampling


Outcome Measures
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Primary Outcome Measures :
  1. Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions [ Time Frame: Up to 16 years ]
  2. Creation of a repository for long-term storage of these specimens [ Time Frame: Up to 16 years ]
  3. Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors [ Time Frame: Up to 16 years ]

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Criteria

Inclusion Criteria:

  • Diagnosis of brain tumor

  • Previously treated at a Children?s Oncology Group (COG) institution

    • Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm
  • Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00919750


Locations
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Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Investigators
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Principal Investigator: Scott Pomeroy Children's Oncology Group
More Information
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Responsible Party: Children's Oncology Group
ClinicalTrials.gov Identifier: NCT00919750    
Obsolete Identifiers: NCT00228748
Other Study ID Numbers: ACNS02B3
NCI-2009-00334 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
COG-ACNS02B3
CDR0000352347
ACNS02B3 ( Other Identifier: Childrens Oncology Group )
ACNS02B3 ( Other Identifier: CTEP )
U10CA098543 ( U.S. NIH Grant/Contract )
UG1CA189958 ( U.S. NIH Grant/Contract )
First Posted: June 12, 2009    Key Record Dates
Last Update Posted: July 16, 2018
Last Verified: July 2018
Additional relevant MeSH terms:
Layout table for MeSH terms
Brain Neoplasms
Medulloblastoma
Neoplasms
Astrocytoma
Meningioma
Ependymoma
Oligodendroglioma
Rhabdoid Tumor
Craniopharyngioma
Adamantinoma
Choroid Plexus Neoplasms
Recurrence
Disease Attributes
Pathologic Processes
Central Nervous System Neoplasms
 Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Glioma
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms, Vascular Tissue
Meningeal Neoplasms
Neuroectodermal Tumors, Primitive