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Prevention of Potentially Inappropriate Prescribing in Late Life Using Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) Criteria

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00915824
Recruitment Status : Unknown
Verified October 2009 by Cork University Hospital.
Recruitment status was:  Active, not recruiting
First Posted : June 8, 2009
Last Update Posted : October 29, 2009
Information provided by:
Cork University Hospital

Brief Summary:

Potentially inappropriate prescribing is common in older patients and encompasses overuse, misuse and underuse of medications. Potentially inappropriate prescribing is associated with negative outcomes including adverse drug events and hospitalization.

STOPP (Screening Tool of Older Person's potentially inappropriate Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) is a new screening tool designed to detect instances of potentially inappropriate medication use and under-prescribing of clinically indicated medications in older patients. The purpose of this study is to determine whether clinical implementation of STOPP/START criteria in hospitalized older patients is effective in improving prescribing quality.

Condition or disease Intervention/treatment Phase
Healthy Other: STOPP/START criteria Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 400 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: Prevention of Potentially Inappropriate Prescribing in Late Life Using STOPP (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions) and START (Screening Tool to Alert Doctors to Right i.e. Appropriate Indicated Treatment): A Randomized Controlled Trial.
Study Start Date : November 2007
Actual Primary Completion Date : June 2009
Estimated Study Completion Date : June 2009

Arm Intervention/treatment
Experimental: STOPP/START intervention
STOPP/START intervention group
Other: STOPP/START criteria
Application of STOPP/START criteria to the patient's prescription and diagnostic information with subsequent written recommendation on pharmaceutical care to the patient's medical team

Primary Outcome Measures :
  1. Appropriateness of prescribing using the Medication Appropriateness Index and the Assessment of Underutilization of Medication Tool [ Time Frame: Measured on admission, discharge and at 2, 4 and 6 months post-discharge ]

Secondary Outcome Measures :
  1. Composite health resource utilization including hospital readmission and primary care consultations [ Time Frame: at 2, 4 and 6 months post-discharge ]

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • All patients aged 65 years and older admitted to the general medical services of Cork University Hospital, Cork, Ireland

Exclusion Criteria:

  • Patient admitted to a geriatric medicine service, psychiatry of old age service or clinical pharmacology service, or under review of these services during the previous 12 months
  • Critically ill patient (admitted to the intensive care unit)
  • Terminally ill patient
  • Refusal of patient or hospital physician to participate
  • No time for the research physician to enrol the patient within 3 days of admission

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00915824

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Cork University Hospital
Cork, Ireland
Sponsors and Collaborators
Cork University Hospital
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Principal Investigator: Paul Gallagher, MB MRCPI Cork University Hospital
Study Director: Denis O'Mahony, MD FRCPI Cork University Hospital
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Responsible Party: Dr. Paul Gallagher, Clinical Research Fellow, Department of Geriatric Medicine, Cork University Hospital Identifier: NCT00915824    
Other Study ID Numbers: CRT2006029
First Posted: June 8, 2009    Key Record Dates
Last Update Posted: October 29, 2009
Last Verified: October 2009
Keywords provided by Cork University Hospital:
Drug therapy
Randomized controlled trial
STOPP/START criteria
Appropriateness of prescribing in older patients
Prescription Drugs