Kidney Function After Pneumoperitoneum and Analgesia
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|ClinicalTrials.gov Identifier: NCT00914875|
Recruitment Status : Completed
First Posted : June 5, 2009
Last Update Posted : June 5, 2009
|Condition or disease|
Background: The laparoscopic cholecystectomy (LC) reduces surgical trauma and hospital stay but requires effective and safe postoperative analgesia. This prospective and double blind study aimed to study the effects of tramadol analgesia associated to dipyrone or ketorolac in the kidney function of patients submitted to LC, using creatinine (Cr), cystatin C, and enzymuria evaluations.
Methods: In the pre- and postoperative (PO) periods, estimated glomerular filtration rates (GFR), obtained from two formulas dependants of blood Cr and one from blood cystatin C values, and tubular enzymuria - alkaline phosphatase (AP), γ-glutamyltransferase (γ-GT) - were determined in patients who underwent LC and analgesia with tramadol and dipyrone (G1, n=63) or tramadol and ketorolac (G2, n=63). In the recovery room (RR), pain and need of rescue analgesia with morphine were evaluated.
|Study Type :||Observational|
|Actual Enrollment :||126 participants|
|Official Title:||Kidney Function After Laparoscopic Cholecystectomy and Tramadol Anesthesia Plus Dipyrone or Ketorolac|
|Study Start Date :||February 2007|
|Actual Primary Completion Date :||November 2007|
|Actual Study Completion Date :||December 2007|
|group tramadol plus ketorolac|
|group tramadol plus dypirone|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00914875
|Botucatu, São Paulo, Brazil, 18600 000|
|Principal Investigator:||Yara M Castiglia, MD, PhD||Botucatu Medical School|