Conditioning With Volatile Anesthetics in Liver Transplantation
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|ClinicalTrials.gov Identifier: NCT00913276|
Recruitment Status : Completed
First Posted : June 4, 2009
Last Update Posted : November 27, 2012
The gap between the number of candidates for orthotopic liver transplantation and the availability of suitable liver grafts has led to a rise in deaths on most waiting lists. Strategies applied in many centers to minimize this deficit include living donation or split of a cadaveric organ for two recipients, domino transplantation, and the use of so-called expanded criteria donors. Alternatively, conditioning of an organ would also allow protec-tion of the liver upon ischemia-reperfusion injury, possibly decreasing postoperative liver function and im-proving clinical outcome. The technique of conditioning with the volatile anesthetic sevoflurane is an easily applicable procedure which could be performed in any center worldwide.
Data and experience with sevoflurane attenuating ischemic-reperfusion injury in liver resection lead to the hypothesis of a beneficial effect of volatile anesthetics in liver transplantation. In this randomized controlled trial, patients will be randomly assigned to liver transplantation with propofol anesthesia (propofol group) or sevoflurane conditioning with the volatile anesthetic (sevoflurane group). Primary endpoint is postoperative peak of the transaminase (AST), secondary endpoints are complications, primary liver graft function, ICU and hospital stay. We hypothesis that patients with conditioning have an attenuated increase of transaminases as well as a better outcome.
|Condition or disease||Intervention/treatment||Phase|
|End-stage Liver Disease||Drug: Propofol Drug: Sevoflurane||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||98 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||January 2009|
|Actual Primary Completion Date :||August 2012|
|Actual Study Completion Date :||October 2012|
- postoperative paek of AST [ Time Frame: 4 y ]
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00913276
|University Hospital Zurich, Division of Anaesthesiology|
|Zurich, ZH, Switzerland, 8091|
|Principal Investigator:||Beatrice Beck Schimmer, Prof MD||University Hospital Zurich, Division of Anaesthesiology|