Repetitive Transcranial Magnetic Stimulation (rTMS) to Promote Hand Recovery in Stroke (rTMS)
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|ClinicalTrials.gov Identifier: NCT00913211|
Recruitment Status : Completed
First Posted : June 4, 2009
Last Update Posted : August 31, 2011
|Condition or disease||Intervention/treatment||Phase|
|Stroke||Device: rTMS Procedure: Motor learning training Procedure: rTMS and Tracking Device: Sham rTMS||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||rTMS and Motor Learning Training to Promote Recovery From Hemiparesis|
|Study Start Date :||September 2007|
|Actual Primary Completion Date :||August 2011|
|Actual Study Completion Date :||August 2011|
Experimental: rTMS only
brain stimulation to non-stroke primary motor area
600 pulses of 6 hz priming rTMS at 90% of threshold followed by 600 pulses of low-frequency rTMS at 90% of threshold.
Experimental: Finger tracking training
Motor learning training using finger flexion/extension tracking movements toward a target.
Procedure: Motor learning training
one hour of repeated finger tracking movements toward a changing target.
Experimental: rTMS and finger tracking
Combination of rTMS and tracking
Procedure: rTMS and Tracking
Combination of rTMS and finger tracking
Placebo Comparator: Sham
Sham rTMS treatment
Device: Sham rTMS
Sham treatment of rTMS
- box and block finger prehension test [ Time Frame: 45 days ]
- cortical excitability [ Time Frame: from pretest to posttest (2 weeks) ]Paired pulse TMS testing will show increase in the ratio of paired pulse to single pulse MEP amplitude when stimulating ipsilesional M1.
- cognitive function [ Time Frame: pretest to posttest (2 weeks) ]There will be no decline in function on the Hopkins Verbal learning test.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00913211
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||James R Carey, PhD||University of Minnesota|