Effects of Aerobe Interval Training and Moderate Continuous Training in Chronic Obstructive Pulmonary Disease Patients
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|ClinicalTrials.gov Identifier: NCT00908765|
Recruitment Status : Completed
First Posted : May 27, 2009
Last Update Posted : January 3, 2013
|Condition or disease||Intervention/treatment||Phase|
|COPD Chronic Obstructive Pulmonary Disease||Behavioral: Exercise||Not Applicable|
Reduced exercise tolerance is one of the hallmarks of COPD and The principal causes for exercise intolerance are ventilatory limitation leading to deconditioning and inactivity. However the weak correlation between exercise capacity and FEV1 implies that other factors than reduced pulmonary function contributes to this impairment . Several studies have found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb dysfunction
Numerous exercise studies in COPD patients have shown physiological and physiological benefits of training and endurance training is now regarded as an important part in pulmonary rehabilitation. It is still uncertain what type of endurance training that is most favourable for COPD patients.
In patients with heart failure and metabolic syndrome aerobe interval exercise have be shown to be superior in improving aerobic capacity and cardiac function
We therefore want conduct a study comparing training effects in patients with moderate to severe COPD, that participated in an identical training program that in HF and metabolic syndrome patients gave significant improvement in aerobic capacity, cardiac function and skeletal muscle function.
Patients will therefore be assigned to either 4x4 minutes high intensity interval treadmill exercise or continuous moderate intensity treadmill exercise 3 times pr week for 12 weeks. Aerobic capacity and work economy, pulmonary,cardiac and skeletal muscle function before and after the exercise training will be measured.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Aerobe Interval Training and Moderate Continuous Training in COPD Patients|
|Study Start Date :||August 2008|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||September 2009|
Active Comparator: Aerobe Interval Training
High aerobic intensity treadmill walking. 4 by 4 minutes interval training on a graded treadmill at a heart rate corresponding to 85-95% of maximal heart rate. 3 times per week for 10 weeks.
Other Name: non
Active Comparator: Moderate Continous Training
Moderate continuous intensity treadmill walking on a graded treadmill at a heart rate corresponding to 60-70 of maximal heart rate, 3 times per week for 10 weeks
Other Name: non
- VO2-peak [ Time Frame: At inclusion and after 12 weeks of exercise training ]
- Cardiac function [ Time Frame: At inclusion and after 12 weeks of exercise training ]
- Skeletal muscle function [ Time Frame: At inclusion and after 12 weeks of exercise training ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00908765
|Department of Circulation and Medical Imaging , NTNU|
|Trondheim, Norway, 7089|
|Principal Investigator:||Sigurd Steinshamn, MD PhD||NTNU , Trondheim|
|Principal Investigator:||Eivind Brønstad, MD||NTNU, Trondheim|