Collection and Storage of Blood and Tissue Samples From Patients Who Are Undergoing Surgery For Lung Cancer
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|ClinicalTrials.gov Identifier: NCT00899782|
Recruitment Status : Active, not recruiting
First Posted : May 12, 2009
Last Update Posted : February 20, 2020
|Condition or disease||Intervention/treatment|
|Lung Carcinoma Lung Neoplasm Malignant Lung Neoplasm||Other: cytology specimen collection procedure|
- To collect, catalog and store frozen samples of lung carcinoma and when possible, portions of involved lymph nodes, as well as adjacent grossly uninvolved lung tissue obtained from surgical specimens of patients undergoing surgical resection for previously untreated lung cancer as a source of quality DNA, messenger ribonucleic acid (mRNA) and protein for molecular analysis.
- To collect, catalog and store frozen samples of blood pre- and post-resection from the same patients to provide a source of reference DNA to assess somatic mutations associated with tumor or preneoplastic "normal" lung, and to allow assessment of levels of circulating markers.
- To associate these specimens with historical, clinical, pathological, and outcome information.
Grossly viable tumor and grossly normal lung tissue are identified and removed from patient surgical specimens and cryopreserved until shipment to the Cancer and Leukemia Group B (CALGB) Lung Cancer Tissue Bank for future use in research. Blood specimens are also collected prior to surgery and at 4-12 weeks post-surgery (before the start of adjuvant therapy) and shipped immediately to the Tissue Bank.
|Study Type :||Observational|
|Estimated Enrollment :||500 participants|
|Official Title:||The CALGB Lung Cancer Tissue Bank|
|Study Start Date :||July 2004|
|Estimated Primary Completion Date :||January 2100|
Ancillary-Correlative (lung cancer tissue bank)
Grossly viable tumor and grossly normal lung tissue are identified and removed from patient surgical specimens and cryopreserved until shipment to the CALGB Lung Cancer Tissue Bank for future use in research. Blood specimens are also collected prior to surgery and at 4-12 weeks post-surgery (before the start of adjuvant therapy) and shipped immediately to the Tissue Bank.
Other: cytology specimen collection procedure
Other Name: cytologic sampling
- Collection and storage of frozen tissue samples for molecular analysisor resection of lung cancer [ Time Frame: Up to 5 years ]
- Collection and storage of frozen blood samples for the assessment of somatic mutations and levels of circulating markersto assess levels of circulating markers [ Time Frame: Up to 5 years ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00899782
|Study Chair:||William Richards, MD||Brigham and Women's Cancer Center|