Study of Hair Samples From Patients With Cancer
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|ClinicalTrials.gov Identifier: NCT00899691|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : March 15, 2012
RATIONALE: Studying samples of hair in the laboratory from patients with cancer may help doctors identify biomarkers related to cancer and predict how well patients will respond to treatment.
PURPOSE: This laboratory study is looking at hair samples from patients with cancer.
|Condition or disease||Intervention/treatment|
|Unspecified Adult Solid Tumor, Protocol Specific||Genetic: protein expression analysis|
- Determine whether layered membrane technology can quantitatively measure the expression, activity, and localization of cell growth control and signaling proteins in hair samples from patients with cancer.
- Correlate changes in protein expression with expected changes based on planned therapy in these patients.
OUTLINE: This is a pilot, multicenter study.
Hair samples are obtained from patients at baseline and at the end of study. The samples are assayed for proteins and phosphorylation status using layered membrane technology. Proteins analyzed may include vascular endothelial growth factor receptor (VEGFR), Erk1/2, Akt, epidermal growth factor receptor (EGFR), and c-KIT.
PROJECTED ACCRUAL: A total of 190 patients will be accrued for this study within 3 years.
|Study Type :||Observational|
|Estimated Enrollment :||190 participants|
|Official Title:||Detection and Quantification of Changes in Levels of Protein Expression and Phosphorylation Status Using Human Hair Samples|
|Study Start Date :||March 2005|
|Actual Study Completion Date :||October 2008|
- Obtain data on the detection and quantification of changes in levels of protein expression and phosphorylation status using human hair samples at baseline and after completion of study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00899691
|Principal Investigator:||Steven K. Libutti, MD||NCI - Surgery Branch|