Tissue Sample Collection From Patients With Fanconi Anemia
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|ClinicalTrials.gov Identifier: NCT00899522|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : December 4, 2017
RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future.
PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.
|Condition or disease||Intervention/treatment|
|Fanconi Anemia Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific||Other: biologic sample preservation procedure Procedure: biopsy|
- Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.
- Study repository tissue using a variety of molecular methods, including gene microarrays.
- Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.
OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.
PROJECTED ACCRUAL: Not specified.
|Study Type :||Observational|
|Actual Enrollment :||8 participants|
|Official Title:||Fanconi Anemia Cancer Cell Repository|
|Study Start Date :||August 2005|
|Actual Primary Completion Date :||March 2013|
|Actual Study Completion Date :||May 2013|
- Other: biologic sample preservation procedure
Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.
- Procedure: biopsy
Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.
- Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia [ Time Frame: Duration of the study ]
- Study tissue samples by molecular methods, including gene microarrays [ Time Frame: Duration of the study ]
- Development of cancer cell lines from tissue archived from patients with Fanconi anemia [ Time Frame: Duration of the study ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00899522
|United States, Oregon|
|Knight Cancer Institute at Oregon Health and Science University|
|Portland, Oregon, United States, 97239-3098|
|Principal Investigator:||Grover C. Bagby, MD||OHSU Knight Cancer Institute|