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Comparing Imaginal Exposure and Imagery Rescripting in Treatment of Posttraumatic Stress Disorder (PTSD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00891098
Recruitment Status : Completed
First Posted : May 1, 2009
Last Update Posted : June 5, 2013
University of Oslo
Information provided by (Responsible Party):
Asle Hoffart, Modum Bad

Brief Summary:
The outcome of trauma treatment (Posttraumatic Stress Disorder - PTSD) may be influenced by which emotions that are predominant among current symptoms, e.g. fear, anger, guilt, shame. Different treatment procedures for processing traumatic memories may resolve different emotions. This study compares two different treatment procedures of working with trauma memories in PTSD treatment (namely, Imaginal Exposure and Imagery Rescripting) in order to test this.

Condition or disease Intervention/treatment Phase
Posttraumatic Stress Disorder Behavioral: Imaginal exposure Behavioral: Imagery rescripting Not Applicable

Detailed Description:

The main objectives of this study are:

  1. To assess the relative efficacy of the two procedures in inpatient treatment for PTSD
  2. To assess whether the predominant emotions in the traumatic memories moderate the outcome of the different procedures
  3. To assess whether theory-derived constructs mediate outcome and whether the mediating relationships are different in the two treatments
  4. To provide a theoretical account of the two models
  5. To psychometrically evaluate 3 new measures

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 65 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Comparing Imaginal Exposure (IE) and Imagery Rescripting and Reprocessing Therapy (IRRT) in the Treatment of Posttraumatic Stress Disorder (PTSD)
Study Start Date : November 2008
Actual Primary Completion Date : November 2012
Actual Study Completion Date : November 2012

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: Imaginal exposure Behavioral: Imaginal exposure
7 individual sessions of imaginal exposure of trauma memories according to the prolonged exposure treatment manual
Other Names:
  • prolonged exposure
  • pe

Experimental: Imagery rescripting Behavioral: Imagery rescripting
7 individual sessions of imagery rescripting of trauma memories according to the imagery rescripting and reprocessing therapy manual
Other Names:
  • rescripting
  • irrt

Primary Outcome Measures :
  1. PTSD symptoms [ Time Frame: pretreatment, weekly during treatment, posttreatment, followup ]

Secondary Outcome Measures :
  1. General psychiatric symptoms [ Time Frame: pretreatment, weekly during treatment, postttreatment, followup ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • DSM-IV diagnosis of PTSD identified as primary diagnosis
  • Accepts withdrawal of all psychotropic medication

Exclusion Criteria:

  • Extensive dissociative symptoms or current psychosis,
  • Current suicidal risk,
  • Extensive current substance or alcohol abuse, or
  • Ongoing trauma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00891098

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Modum Bad
Vikersund, Buskerud, Norway, 3370
Sponsors and Collaborators
Modum Bad
University of Oslo
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Study Chair: Asle Hoffart, PhD Modum Bad and University of Oslo
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Responsible Party: Asle Hoffart, phd, Modum Bad Identifier: NCT00891098    
Other Study ID Numbers: 2-Hoffart
First Posted: May 1, 2009    Key Record Dates
Last Update Posted: June 5, 2013
Last Verified: June 2013
Additional relevant MeSH terms:
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Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Trauma and Stressor Related Disorders
Mental Disorders