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Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00877435
Recruitment Status : Completed
First Posted : April 7, 2009
Last Update Posted : January 29, 2015
Information provided by (Responsible Party):
Sylvie Petitjean, University Hospital, Basel, Switzerland

Brief Summary:
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT only. Patients were randomized to prizeCM + CBT (experimental group) or to CBT (control group) an treated over 24 weeks. It is the first trial of this type in Europe.

Condition or disease Intervention/treatment Phase
Cocaine-related Disorders Behavioral: Cognitive behavioral therapy (CBT) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial
Study Start Date : September 2008
Actual Primary Completion Date : August 2013
Actual Study Completion Date : October 2014

Arm Intervention/treatment
Experimental: 1
Cognitive behavioral therapy (CBT) + prize-based contingency management (prizeCM)
Behavioral: Cognitive behavioral therapy (CBT)
Active Comparator: 2
Cognitive behavioral therapy (CBT)
Behavioral: Cognitive behavioral therapy (CBT)

Primary Outcome Measures :
  1. retention in treatment, cocaine abstinence [ Time Frame: 24 weeks ]
    cocaine abstinence: at least 3 consecutive weeks of cocaine abstinence, the maximum number of weeks of continous abstinence and proportions of cocaine-free urine samples during the entire 24-week and at 6-month follow-up.

Secondary Outcome Measures :
  1. patients' satisfaction with the therapy, clinical measures [ Time Frame: 24 weeks ]
    patients' satisfaction with prize-based contingency management and with CBT

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • cocaine dependence, aged 18 or older, other dependences

Exclusion Criteria:

  • severe somatic, brain, or psychiatric disease, attention deficit disorders with medication methylphenidate

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00877435

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Universitäre Psychiatrischen Kliniken
Basel, Switzerland, 4025
Fondation Phenix
Geneva, Switzerland, 1221
Sponsors and Collaborators
University Hospital, Basel, Switzerland
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Principal Investigator: Sylvie A Petitjean, Dr. phil. Psychiatric Hospital of the University of Basel
Additional Information:
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Responsible Party: Sylvie Petitjean, Dr. phil, University Hospital, Basel, Switzerland Identifier: NCT00877435    
Other Study ID Numbers: SNF-105314-120675
First Posted: April 7, 2009    Key Record Dates
Last Update Posted: January 29, 2015
Last Verified: January 2015
Additional relevant MeSH terms:
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Cocaine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders