Impact of Sperm DNA Integrity on Artificial Reproductive Treatment (ART)
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ClinicalTrials.gov Identifier: NCT00875095 |
Recruitment Status :
Terminated
(Study funding was withdrawn by the sponsor following agreement that slow patient recruitment warranted a new approach.)
First Posted : April 3, 2009
Last Update Posted : September 8, 2016
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Condition or disease |
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Sperm DNA Impact on ART Outcomes |
Study Type : | Observational |
Actual Enrollment : | 8 participants |
Observational Model: | Case-Only |
Time Perspective: | Cross-Sectional |
Official Title: | Impact of Sperm DNA Integrity on ART Treatment |
Study Start Date : | October 2007 |
Actual Primary Completion Date : | December 2008 |
Actual Study Completion Date : | December 2008 |

Group/Cohort |
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IUI patients
Patients undergoing routine semen analysis as part of their infertility treatment pertaining to success or failure with intrauterine insemination, based upon their sperm DNA integrity
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IVF patients
Couples undergoing routine screening prior to IVF retrievals to assess their reproductive treatment outcomes as compared to the sperm DNA integrity
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- Sperm DNA integrity [ Time Frame: 1 day ]
- achievement of a successful pregnancy [ Time Frame: 1 year ]
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- needs interventions through artificial reproductive treatment to achieve a pregnancy
Exclusion Criteria:
- severly oligozoospermic patients

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00875095
United States, New York | |
The Center for Human Reproduction | |
Manhasset, New York, United States, 11030 |
Principal Investigator: | Avner Hershlag, MD | Northwell Health | |
Study Director: | Dennis E Marchesi, MSc | Northwell Health |
Responsible Party: | Dennis Marchesi, laboratory supervisor, Northwell Health |
ClinicalTrials.gov Identifier: | NCT00875095 |
Other Study ID Numbers: |
07.08.118 |
First Posted: | April 3, 2009 Key Record Dates |
Last Update Posted: | September 8, 2016 |
Last Verified: | September 2016 |
sperm DNA integrity Toluidine blue staining |