High Frequency Chest Wall Oscillation in Chronic Obstructive Pulmonary Disease (COPD)
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|ClinicalTrials.gov Identifier: NCT00863616|
Recruitment Status : Completed
First Posted : March 18, 2009
Last Update Posted : March 18, 2009
Patients with Chronic obstructive pulmonary disease (COPD) tend to have cough, excess mucus production and breathlessness as cardinal features. The excess mucus production often leads to frequent infections, exacerbations and poor quality of life. Mucociliary clearance may have an impact on improving symptoms, exercise tolerance, quality of life and reduce exacerbations.
High frequency chest wall oscillation(HFCWO) devices use percussion to the chest wall delivered from a pump through a close fitting inflatable vest. This technique has been shown to enhance mucus clearance in patients with cystic fibrosis and Bronchiectasis. This pilot study was designed to explore the feasibility, tolerance and effectiveness of the HFCWO in patients with advanced COPD.
|Condition or disease||Intervention/treatment||Phase|
|Chronic Obstructive Pulmonary Disease||Device: HFCWO - SmartVest||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||32 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Self-Administered High Frequency Chest Wall Oscillation Technique for Mucus Clearance in COPD: An Exploratory Pilot Project Using the SMARTVEST Device|
|Study Start Date :||August 2006|
|Actual Primary Completion Date :||October 2007|
|Actual Study Completion Date :||October 2007|
HFCWO twice a day delivered by SmartVest device at 13Hz FOR 20min x2. Duration 4 weeks in each phase with a 2week washout.
Device: HFCWO - SmartVest
SmartVest with vest administered for 20min at 11-13Hz
Other Name: SmartVest
No Intervention: Placebo/Control
Self-administered breathing exercises
- Health related quality of life (St George's Respiratory Questionnaire) [ Time Frame: 3 months ]
- Exercise tolerance (Endurance Shuttle Walk Time achieved) [ Time Frame: 3 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00863616
|East & North Herts NHS Trust|
|Stevenage, Herts, United Kingdom, SG1 4AB|
|Principal Investigator:||Indranil Chakravorty, PhD, MRCP||East & North Herts NHS Trust, Stevenage, Herts, UK|