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Influence of Protein Source on Satiety and Metabolism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00862329
Recruitment Status : Completed
First Posted : March 16, 2009
Last Update Posted : March 22, 2012
Sponsor:
Collaborator:
National Research Agency, France
Information provided by (Responsible Party):
Robert Benamouzig, Institut National de la Recherche Agronomique

Brief Summary:
Dietary protein is the more satiating nutrient, however it is not clear whether satiety may be influenced by the nature of the protein. This study was designed to assess potential differences between protein sources on satiety and their relationship with digestive and metabolic kinetics.

Condition or disease Intervention/treatment Phase
Healthy Dietary Supplement: Casein-enriched diet Dietary Supplement: Milk soluble protein-enriched diet Dietary Supplement: Casein and milk soluble proteins-enriched diet Dietary Supplement: Soy proteins-enriched diet Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Study Start Date : March 2008
Actual Primary Completion Date : June 2009
Actual Study Completion Date : November 2010

Resource links provided by the National Library of Medicine

Drug Information available for: Casein

Arm Intervention/treatment
Experimental: Casein Dietary Supplement: Casein-enriched diet
Subjects consume for 9 days a supplement of 30g/d of casein

Experimental: MSP Dietary Supplement: Milk soluble protein-enriched diet
Subjects consume for 9 days a supplement of 30g/d of milk soluble protein

Experimental: Casein/MSP Dietary Supplement: Casein and milk soluble proteins-enriched diet
Subjects consume for 9 days a supplement of 30g/d of a mix of casein and milk soluble protein

Experimental: Soy protein Dietary Supplement: Soy proteins-enriched diet
Subjects consume for 9 days a supplement of 30g/d of soy protein




Primary Outcome Measures :
  1. satiety [ Time Frame: 7 days ]

Secondary Outcome Measures :
  1. hormonal profiles, digestive fluxes of nutrients, postprandial dietary N metabolism [ Time Frame: 9 days ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI between 25 and 30

Exclusion Criteria:

  • allergy to milk proteins

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00862329


Locations
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France
Centre de recherche sur volontaires
Bobigny, France, 93
Sponsors and Collaborators
Institut National de la Recherche Agronomique
National Research Agency, France
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Robert Benamouzig, Manager of the HNRC, Institut National de la Recherche Agronomique
ClinicalTrials.gov Identifier: NCT00862329    
Other Study ID Numbers: SURPROL
First Posted: March 16, 2009    Key Record Dates
Last Update Posted: March 22, 2012
Last Verified: March 2012
Keywords provided by Robert Benamouzig, Institut National de la Recherche Agronomique:
Healthy subjects
Additional relevant MeSH terms:
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Caseins
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action