Gene-expression Profiles in CNS-metastatic Non-small Cell Lung Cancer
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ClinicalTrials.gov Identifier: NCT00862173 |
Recruitment Status : Unknown
Verified June 2012 by DR. MYRNA CANDELARIA, National Institute of Cancerología.
Recruitment status was: Recruiting
First Posted : March 16, 2009
Last Update Posted : June 12, 2012
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Condition or disease |
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Brain Disease Metastasis Lung Cancer |

Study Type : | Observational |
Estimated Enrollment : | 120 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Gene-expression Profile as Predictor of Central Nervous System Metastasis Development in Non-small Cell Lung Cancer: a Prospective Study |
Study Start Date : | March 2008 |
Estimated Primary Completion Date : | December 2012 |
Estimated Study Completion Date : | December 2012 |

Group/Cohort |
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Patients with NSCLC with CNS Metastasis
Patients who developed CNS metastasis of NSCLC during the treatment.
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Patients with NSCLC without CNS Metastasis
Patients with NSCLC that does not develop CNS metastasis during the treatment.
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- Central nervous system metastasis development [ Time Frame: 8 months ]
- Death [ Time Frame: 18 months ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Age > 18 years
- With auto-sufficiency
- Biopsy procedure approved
- Any TNM status
- Consulting at the National Institutes of Cancerology or Respiratory Diseases
- Informed consent signed
Exclusion Criteria:
- Comorbidity with other cancer type, hereditary or autoimmune diseases and treatment with immunosuppressor drugs
- Previous treatment with adjuvant or neoadjuvant chemo- or radiotherapy
- No specimen availability
- No diagnosis of non-small-cell lung cancer at histopathology sample

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00862173
Contact: Oscar Arrieta, MD | 01525556280400 ext 832 | ogar@servidor.unam.mx | |
Contact: David Saavedra-Perez, MD | 0152 5558634488 | seelowen@msn.com |
Mexico | |
Instituto Nacional de Cancerología | Recruiting |
Mexico City, Mexico, 14080 | |
Contact: Oscar Arrieta, MD 015255 56280400 ext 832 ogar@servidor.unam.mx | |
Principal Investigator: David Saavedra-Pérez, MD | |
Instituto Nacional de Enfermedades Respiratorias | Recruiting |
Mexico City, Mexico, 14080 | |
Contact: Enrique Guzmán, MD 015255 56664539 ext 5120 enriqueg@prodigy.net.mx | |
Sub-Investigator: Enrique Guzmán, MD |
Principal Investigator: | David Saavedra-Pérez, MD | Instituto Nacional de Cancerología | |
Study Chair: | Oscar Arrieta, MD | Instituto Nacional de Cancerología | |
Study Director: | Enrique Guzmán, MD | Instituto Nacional de Enfermedades Respiratorias | |
Study Director: | Gabriela Mercado, MSc | Instituto Nacional de Medicina Genómica | |
Study Director: | Elena Aréchaga, PhD | Instituto Nacional de Cancerología | |
Study Director: | Claudia González, PhD | Metropolitan Autonomous University | |
Study Director: | Digna Pachuca, MD | Instituto Nacional de Cancerología |
Responsible Party: | DR. MYRNA CANDELARIA, Gene expression Profiles in CNS metastasic Non small Cell Lung Cancer, National Institute of Cancerología |
ClinicalTrials.gov Identifier: | NCT00862173 |
Other Study ID Numbers: |
008/025/OMI |
First Posted: | March 16, 2009 Key Record Dates |
Last Update Posted: | June 12, 2012 |
Last Verified: | June 2012 |
Gene-expression profile Central nervous system metastasis Non-small-cell lung cancer |
Lung Neoplasms Carcinoma, Non-Small-Cell Lung Neoplasm Metastasis Brain Diseases Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms |
Lung Diseases Respiratory Tract Diseases Carcinoma, Bronchogenic Bronchial Neoplasms Neoplastic Processes Pathologic Processes Central Nervous System Diseases Nervous System Diseases |