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Effect of Monosodium Glutamate Supplementation on Gastric Emptying and Postprandial Nitrogen Kinetics

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00862017
Recruitment Status : Completed
First Posted : March 16, 2009
Last Update Posted : March 16, 2009
Information provided by:
Institut National de la Recherche Agronomique

Brief Summary:
There are receptors to free glutamate in the oral cavity and stomach that may mediate effects of this amino acid on gastrointestinal physiology. The investigators hypothesize that a chronic supplementation of monosodium glutamate (MSG) could modulate gastric emptying and the further metabolism of dietary protein in healthy subjects.

Condition or disease Intervention/treatment Phase
Healthy Dietary Supplement: MSg supplementation Dietary Supplement: NaCl supplementation Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 13 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science
Official Title: Effect of Monosodium Glutamate on Gastric Emptying and Postprandial Nitrogen in Healthy Volunteers
Study Start Date : April 2008

Arm Intervention/treatment
Experimental: MSG
Subjects receive a 6-d supplementation of MSG and are studied on the 7th day in the postprandial period following a standard meal ingestion with 2g MSG
Dietary Supplement: MSg supplementation
Placebo Comparator: Control Dietary Supplement: NaCl supplementation

Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • BMI 23 to 28

Exclusion Criteria:

  • pregnancy
  • allergy to milk protein
  • gastrointestinal diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00862017

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Centre de recherche sur volontaires
Bobigny, France, 93
Sponsors and Collaborators
Institut National de la Recherche Agronomique
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Pr Benamouzig, Assistance Publique - Hopitaux de Paris Identifier: NCT00862017    
Other Study ID Numbers: AJI-01
First Posted: March 16, 2009    Key Record Dates
Last Update Posted: March 16, 2009
Last Verified: March 2009
Keywords provided by Institut National de la Recherche Agronomique: