Myocardial Stress Perfusion Imaging With Dual Source CT
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|ClinicalTrials.gov Identifier: NCT00853671|
Recruitment Status : Completed
First Posted : March 2, 2009
Results First Posted : December 17, 2018
Last Update Posted : December 17, 2018
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease||Other: Adenosine Stress Dual-source CTP||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Myocardial Stress Perfusion Imaging With Dual Source CT|
|Study Start Date :||April 2008|
|Actual Primary Completion Date :||April 2010|
|Actual Study Completion Date :||April 2010|
Experimental: Adenosine Stress Dual-source CTP
A multiphase adenosine Stress Dual-source stress perfusion computed tomography imaging test, as described above, will be performed in all patients.
Other: Adenosine Stress Dual-source CTP
Adenosine- continuous infusion at 140mcg/ kg/ min for 2.5 min; Iopamidol (IV contrast)- total dose of 150cc; Siemens SOMATOM Definition CT scanner (CT scan radiation) - effective radiation dose of approximately 13mSv (tube voltage 120kV, tube current 340mAs for one retrospectively gated cardiac CT with tube current modulation and two prospectively gated cardiac CTs on a Dual Source scanner)
This is an observational trial, and all patients will undergo the Adenosine Stress Dual-source CTP procedure.
- Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography. [ Time Frame: 18 months ]The gold standard for abnormality by CTP is defined as a focal stenosis of >50% at quantitative analysis of invasive coronary angiography images, when performed.
- Per-Vessel Specificity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography. [ Time Frame: 18 months ]The gold standard for abnormality by CTP is defined as stenosis of 50% or more at quantitative analysis of invasive coronary angiography images, when performed.
- Per-Patient Correlation Between CTP and SPECT at Stress. [ Time Frame: 18 months ]Pearson Correlation between research interpretation of CTP images and SPECT images, both performed during stress.
- Per-Patient Correlation Between CTP and SPECT at Rest. [ Time Frame: 18 months ]Pearson Correlation performed on myocardial abnormalities on CTP and SPECT images, obtained at rest.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00853671
|United States, Massachusetts|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Brian B Ghoshhajra, MD||Massachusetts General Hospital|
|Study Director:||Ricardo C Cury, MD||Massachusetts General Hospital, Baptist Hospital, Miami|