A Trial of Complete Versus Selective HepaticVascular Clamping in Hepatectomy
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|ClinicalTrials.gov Identifier: NCT00851968|
Recruitment Status : Completed
First Posted : February 26, 2009
Last Update Posted : April 1, 2016
|Condition or disease||Intervention/treatment||Phase|
|Hepatocellular Carcinoma||Procedure: Pringle's Maneuver Procedure: Hemihepatic vascular Clamping Procedure: Portal vein occlusion||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||320 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Prospective Randomized Controlled Trial of Complete Versus Selective HepaticVascular Clamping in Hepatectomy|
|Study Start Date :||December 2008|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||December 2010|
Active Comparator: Pringle's Maneuver
Patients with HCC received Pringle's Maneuver in hepatectomy.
Procedure: Pringle's Maneuver
The entire hilar pedicle was encircled with a rubber tape to perform a Pringle maneuver with a tourniquet.
Other Name: Pringle's Maneuver group
Experimental: Hemihepatic vascular Clamping
Patients with HCC received Hemihepatic vascular Clamping in hepatectomy
Procedure: Hemihepatic vascular Clamping
The portal vein,hepatic artery ,and biliary duct were dissected in the hilum by opening the peritoneal fascia. Either the right or left portal pedicle was isolated and encircled with a tourniquet or clamped with Shatinsky clamp. Separate clamping of accessory left hepatic artery was performed when present in controlling the left hemihepatic portal traid.
Other Name: Hemihepatic vascular Clamping group
Experimental: portal vein occlusion
Patients with HCC received portal vein occlusion in hepatectomy
Procedure: Portal vein occlusion
The proper hepatic artery was dissected first from the duodenohepatic ligament, portal pedicle was blocked with a rubber encircled through the posterior wall of proper hepatic artery and the bottom of duodenohepatic ligament.When aberrant hepatic arteries emerging from the superior mesenteric artery are found in duodenohepatic ligament ,they should be dissected and kept unobstructed.
Other Name: Portal vein occlusion group
- overall survival [ Time Frame: 2010 ]
- serum alanine aminotransferase (ALT), bilirubin, prothrombin time, serum albumin and pre-albumin on postoperative 1, 3, 7 day, resection rate, procedure-related complications and hospital mortality,expression of HIF and P-, E-, and L-selectin [ Time Frame: 2010 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00851968
|Eastern Hepatobiliary Surgery Hospital|
|Shanghai, Shanghai, China, 200438|
|Study Chair:||Shen feng, MD||Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University|