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Heart Rate Variability During Weaning From Mechanical Ventilation

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ClinicalTrials.gov Identifier: NCT00851825
Recruitment Status : Completed
First Posted : February 26, 2009
Last Update Posted : May 8, 2009
Sponsor:
Information provided by:
Hospital de Clinicas de Porto Alegre

Brief Summary:
The discontinuation of mechanical ventilation (MV) and the recovery of spontaneous breathing can lead to important cardiovascular alterations due to changes in the intrathoracic pressure. The autonomic modulation assessed through heart rate variability (HRV) during weaning from MV and its impact on cardiorespiratory variables has not been well elucidated yet. To evaluate the effect of T-tube (TT) and pressure support ventilation (PSV) during weaning from MV on cardiorespiratory variables and heart rate variability.

Condition or disease
Critical Care Weaning

Detailed Description:
Thirty patients who had received MV for ≥ 48 hours and who met the criteria for weaning were assessed. Two different weaning methods were used and randomization was performed to choose one of the following sequences (baseline, PSV, rest, TT; or baseline, TT, rest, PSV). HRV was assessed by heart rate spectral analysis during MV, PSV, and TT. Each intervention lasted 30 minutes and there was a 30-minute rest period between the interventions. At the end of each period of time, the following cardiorespiratory variables were analyzed: respiratory rate (f), minute ventilation (VE), tidal volume (VT), rapid shallow breathing index (f/VT), peripheral oxygen saturation (SpO2), heart rate (HR) and blood pressure. In the HRV, the total spectral power (TP), the low frequency (LF) and the high frequency (HF) components, and the ratio between the low/high frequency (LF/HF) components were calculated.

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Study Type : Observational
Actual Enrollment : 30 participants
Time Perspective: Cross-Sectional
Official Title: The Effect of T-Tube and Pressure Support on Cardiorespiratory Variables and Heart Rate Variability During Weaning From Mechanical Ventilation
Study Start Date : March 2003
Actual Study Completion Date : June 2007



Primary Outcome Measures :
  1. heart rate variability analysis [ Time Frame: minutes ]

Secondary Outcome Measures :
  1. Cardiorespiratory variables [ Time Frame: minutes ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with respiratory failure receiving MV for more than 48 hours, who had been admitted to the Intensive Care Unit (ICU) of the Hospital de Clínicas de Porto Alegre, and who met the criteria for weaning from MV according to the parameters previously defined were selected to participate in this study.
Criteria

Inclusion Criteria:

  • Patients with respiratory failure receiving MV for more than 48 hours
  • for weaning from MV according to the parameters previously defined were selected to participate in this study

Exclusion Criteria:

  • arterial hypotension (systolic blood pressure < 100mmHg), severe brain disease, barotraumas, presence of thoracic drain or tracheostomy, using vasoactive and sedative drugs

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00851825


Locations
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Brazil
Federal University of Rio Grande do Sul
Porto Alegre, RS, Brazil
Sponsors and Collaborators
Hospital de Clinicas de Porto Alegre
Investigators
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Principal Investigator: Silvia R Veira, PhD Hospital de Clínicas de Porto Alegre

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Responsible Party: Silvia Regina Rios Vieira, Hospital de Clinicas de Porto Alegre
ClinicalTrials.gov Identifier: NCT00851825     History of Changes
Other Study ID Numbers: 03-435
First Posted: February 26, 2009    Key Record Dates
Last Update Posted: May 8, 2009
Last Verified: May 2009
Keywords provided by Hospital de Clinicas de Porto Alegre:
autonomic modulation
heart rate
pressure support ventilation
T-tube
Mechanical ventilation