Examining the Role of Vitamin D in Asthma and Chronic Obstructive Pulmonary Disease (COPD)
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|ClinicalTrials.gov Identifier: NCT00851695|
Recruitment Status : Completed
First Posted : February 26, 2009
Last Update Posted : August 13, 2012
|Condition or disease|
|Asthma Pulmonary Disease Chronic Obstructive|
Asthma and COPD are among the leading causes of illness in children and adults, respectively. Asthma is the most common long-term disease among children in the developed world, and approximately 16 million people in the United States have COPD, which is now the fourth most common cause of death in this country. Vitamin D, both a nutrient and a hormone, can be taken in through diet and exposure to sunlight. Many children and adults have a vitamin D deficiency and there is concern that current recommended intake levels may be inadequate. A vitamin D deficiency can cause immune system dysfunction and may increase the risk of developing immune-mediated disorders, such as multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis, and various cancers. Because of its role in immune development and function, a vitamin D deficiency may also be related to the development of severe asthma in children and to greater lung function decline in adults, leading to COPD. Preliminary research shows that people with asthma who take vitamin D have an enhanced response to corticosteroids, a common medication used to treat asthma. This finding suggests that vitamin D could possibly be used to improve asthma treatment. The purpose of this study is to measure vitamin D levels in participants of three previous studies and determine whether lower vitamin D levels are related to the development of severe asthma or COPD.
This study will examine previously collected blood samples from participants in three studies. There will be no study visits specifically for this study. The three studies include the following:
- Childhood Asthma Management Program, which is a study that examined the use of inhaled corticosteroids, nedocromil, and placebo in children with mild-to-moderate asthma
- Genetic Epidemiology of Asthma in Costa Rica, which is an ongoing study that is identifying genetic predictors of asthma in Costa Rican families with asthma
- Normative Aging Study, which is a study of aging that is being conducted in men living in Boston
|Study Type :||Observational|
|Actual Enrollment :||2266 participants|
|Official Title:||Vitamin D in Obstructive Lung Diseases|
|Study Start Date :||July 2007|
|Actual Primary Completion Date :||June 2010|
|Actual Study Completion Date :||June 2010|
All 1024 participants of the Childhood Asthma Management Program, who provided blood samples.
Asthma in Hispanics
All 616 subjects in the Genetic Epidemiology of Asthma in Costa Rica who have serum.
Lung function and lung function decline
626 subjects from the Normative Aging Study who have serum and lung function.
- Asthma exacerbation [ Time Frame: Measured at Year 4 in the original study ]
- Lung function decline [ Time Frame: Measured at Year 15 in the original study ]
- Allergy markers [ Time Frame: Measured at Year 4 in the original study ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00851695
|Principal Investigator:||Augusto A. Litonjua, MD, MPH||Brigham and Women's Hospital|