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Stromal Gene Expression During Pulmonary Sarcoidosis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00837668
Recruitment Status : Terminated (Interim analysis)
First Posted : February 5, 2009
Last Update Posted : June 14, 2017
Information provided by (Responsible Party):
Elliott Crouser MD, Ohio State University

Brief Summary:
to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis. By so doing, we hope to identify unique genetic mechanisms which will aid in the diagnosis of sarcoidosis and will help us understand the pathogenesis of this poorly understood disease.

Condition or disease

Detailed Description:
to collect small sample of lung tissue recovered from a clinical procedure such as bronchoscopy, or a mediastinoscopy (a procedure in which a lighted instrument (mediastinoscope) is inserted through a neck incision to visually examine the structures in the top of the chest cavity and to take a sample (biopsy) of tissue.

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Study Type : Observational
Estimated Enrollment : 110 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Stromal Gene Expression During Pulmonary Sarcoidosis
Study Start Date : April 2005
Actual Primary Completion Date : February 2012
Actual Study Completion Date : February 2012

Resource links provided by the National Library of Medicine

sarcoidosis patients undergoing clinical bronchoscopy

Primary Outcome Measures :
  1. To Identify Gene Expression Patterns That Specifically Correlate With Active Pulmonary Sarcoidosis. [ Time Frame: end of study ]

Secondary Outcome Measures :
  1. To Determine if Gene Expression Patterns Correlate With The Severity of Illness Of Sarcoidosis Patients [ Time Frame: end of study ]

Biospecimen Retention:   Samples With DNA
lung tissue

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients from sarcoidosis clinic

Inclusion Criteria:

  • diagnosis of sarcoidosis

Exclusion Criteria:

  • inability to provide consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00837668

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United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
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Principal Investigator: Elliott Crouser, MD Ohio State University
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Responsible Party: Elliott Crouser MD, Associate Professor of Internal Medicine, Ohio State University Identifier: NCT00837668    
Other Study ID Numbers: 2005H0018
First Posted: February 5, 2009    Key Record Dates
Last Update Posted: June 14, 2017
Last Verified: June 2017
Keywords provided by Elliott Crouser MD, Ohio State University:
stromal gene expression
pulmonary sarcoidosis
Additional relevant MeSH terms:
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Sarcoidosis, Pulmonary
Lymphoproliferative Disorders
Lymphatic Diseases
Lung Diseases, Interstitial
Lung Diseases
Respiratory Tract Diseases