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Exercise Training in Asthma

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ClinicalTrials.gov Identifier: NCT00820716
Recruitment Status : Terminated (Difficulties in recruiting patient)
First Posted : January 12, 2009
Last Update Posted : July 14, 2020
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France

Study Description
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Brief Summary:
The aim of the study is to compare two methods of exercise training: alternate load versus constant load realized at moderate or high intensities, in order to define the interests and the limits of each one of these two methods. The finality is to make possible to the expert to choose what exercise training induces the best results quickly and to make its choice according to the therapeutic objectives which it lays down.We also evaluate the effects of these exercises training on the vagal response and the bronchial tone of the asthmatics. From a clinical point of view, a close attention will be paid to the effects of these exercises training on the control of asthma and the quality of life of the subjects

Condition or disease Intervention/treatment Phase
Asthma Other: Exercise training Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 2 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Official Title: Comparison of Two Types of Exercise Training for Asthmatic Subjects : Interests and Limits
Actual Study Start Date : September 21, 2009
Actual Primary Completion Date : October 15, 2010
Actual Study Completion Date : October 15, 2010

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Arms and Interventions
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Arm Intervention/treatment
Experimental: CA
Exercise training with alternate load
 Other: Exercise training
Comparison of two methods of exercise training: alternate load versus constant load realized at moderate or high intensities
Active Comparator: CC
Exercise training with constant load
 Other: Exercise training
Comparison of two methods of exercise training: alternate load versus constant load realized at moderate or high intensities


Outcome Measures
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Primary Outcome Measures :
  1. Maximal oxygen consumption (VO2max) [ Time Frame: At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training ]
  2. Maximal power output (Pmax) [ Time Frame: At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training ]

Secondary Outcome Measures :
  1. Exhaled NO (eNO) [ Time Frame: At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training ]
  2. Heart rate variability [ Time Frame: At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training ]
  3. Force Expiratory Volume in one second (FEV1) [ Time Frame: At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 18 to 45 years old
  • mild to moderate persistent asthma (GINA classification)
  • stabilized asthma
  • physical activity level between 5 and 11 (Baecke and coll, 1982)
  • no contra-indication for physical training

Exclusion Criteria:

  • cardiovascular pathology
  • metabolic pathology
  • traumatic pathology
  • BMI≥30
  • tobacco
  • diabetes
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00820716


Locations
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France
Service de Physiologie et d'Explorations Fonctionnelles - Pôle de Pathologie Thoracique - Nouvel Hôpital Civil
Strasbourg, France, 67 091
Service de Pneumologie - Pôle de Pathologie Thoracique - Nouvel Hôpital Civil
Strasbourg, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
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Study Director: Evelyne LONSDORFER, MD Hôpitaux Universitaires de Strasbourg
More Information
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Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00820716    
Other Study ID Numbers: 3825
2006-A00090-51
First Posted: January 12, 2009    Key Record Dates
Last Update Posted: July 14, 2020
Last Verified: August 2011
Keywords provided by University Hospital, Strasbourg, France:
Asthma
Asthmatic subjects
Exercise training
Constant load
Alternate load
Additional relevant MeSH terms:
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Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
 Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases