MRI Markers of Cartilage Damage in Knee With Osteoarthritis
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ClinicalTrials.gov Identifier: NCT00820430 |
Recruitment Status :
Completed
First Posted : January 12, 2009
Last Update Posted : January 12, 2009
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Condition or disease | Intervention/treatment |
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Osteoarthritis, Knee | Other: Magnetic Resonance Imaging |
Study Type : | Observational |
Actual Enrollment : | 53 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | A Multi-Center Trial on MR Image Markers of Knee Articular Cartilage Damage in Osteoarthritis |
Study Start Date : | November 2006 |
Actual Primary Completion Date : | May 2008 |
Actual Study Completion Date : | May 2008 |

Group/Cohort | Intervention/treatment |
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Control--Non-Osteoporotic Knee
Kellgren-Lawrence (KL) scale score of 0, Age: 18-35 years
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Other: Magnetic Resonance Imaging
Subjects will undergo 4 sequential MRI evaluations of the target knee within a 4 week period to calculate precision error (ICC) in determination of cartilage morphometry (cartilage volume, mean thickness, and surface area), cartilage collagen (regional cartilage T2), and cartilage proteoglycan (regional cartilage T1rho).
Other Names:
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Minimal Osteoarthritis, Knee
Kellgren-Lawrence (KL) scale score of 1 or 2, Age: Older than 18; no upper limit
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Other: Magnetic Resonance Imaging
Subjects will undergo 4 sequential MRI evaluations of the target knee within a 4 week period to calculate precision error (ICC) in determination of cartilage morphometry (cartilage volume, mean thickness, and surface area), cartilage collagen (regional cartilage T2), and cartilage proteoglycan (regional cartilage T1rho).
Other Names:
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Moderate Osteoarthritis, Knee
Kellgren-Lawrence (KL) scale score of 3, Age: Older than 18; no upper limit
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Other: Magnetic Resonance Imaging
Subjects will undergo 4 sequential MRI evaluations of the target knee within a 4 week period to calculate precision error (ICC) in determination of cartilage morphometry (cartilage volume, mean thickness, and surface area), cartilage collagen (regional cartilage T2), and cartilage proteoglycan (regional cartilage T1rho).
Other Names:
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- The primary study goals are to develop and evaluate MRI techniques that minimize systematic errors in measuring knee cartilage, and to assess the reproducibility of MRI techniques comparing normal and osteoarthritic knees across institutions. [ Time Frame: 4 sequental MRI evaluations of the target knee within a 4-week period ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Participants must be >18 years old;
- Participants must have a KL score between 0 and 3;
- Participants must have clearance to use protocol specified equipment: 3T MRI with parallel imaging capability and phased array knee coil (minimum 4 elements);
- Participant had no change of treatment occur within the last 6 months;
- Participants have no plans of changing to a different treatment within the next 3 months;
- Participant must provide a study-specific signed informed consent form.
Exclusion Criteria:
- Patients with contraindication to 3T MRI: Claustrophobia, Implanted metal or medical device that is not approved for MRI scanning at 3T, pregnancy, inability to tolerate relative immobility for 1 hour;
- Patients with prior knee surgery or trauma of the knee;
- Patients with KL score of 4.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00820430
United States, Pennsylvania | |
Penn State Milton S. Hershey Medical Center | |
Hershey, Pennsylvania, United States, 17033 | |
Thomas Jefferson University Hospital | |
Philadelphia, Pennsylvania, United States, 19017 | |
University of Pennsylvania | |
Philadelphia, Pennsylvania, United States, 19104 | |
Fox Chase Cancer Center | |
Philadelphia, Pennsylvania, United States, 19111 | |
University of Pittsburgh Medical Center | |
Pittsburgh, Pennsylvania, United States, 15213 |
Principal Investigator: | Timothy J Mosher, MD | Milton S. Hershey Medical Center | |
Study Chair: | Ravinder Reddy, PhD | University of Pennsylvania, MMRRCC |
Responsible Party: | Timothy J. Mosher, MD, Penn State Milton S. Hershey Medical Center |
ClinicalTrials.gov Identifier: | NCT00820430 |
Other Study ID Numbers: |
ACRIN PA 4001 SAP #4100026182 |
First Posted: | January 12, 2009 Key Record Dates |
Last Update Posted: | January 12, 2009 |
Last Verified: | January 2009 |
osteoarthritis knee magnetic resonance imaging knee cartilage reproducibility |
Osteoarthritis Osteoarthritis, Knee Arthritis |
Joint Diseases Musculoskeletal Diseases Rheumatic Diseases |