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The Epidemiology of Aortic Diameter in China

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00820378
Recruitment Status : Unknown
Verified January 2009 by Zhejiang University.
Recruitment status was:  Recruiting
First Posted : January 12, 2009
Last Update Posted : January 14, 2009
Sponsor:
Collaborator:
Taizhou Hospital
Information provided by:
Zhejiang University

Brief Summary:
Aortic aneurysms are the major disease processes affecting the aorta and becoming a relatively common cause of death because of rupture or dissection. The most common location for aneurysms is the infrarenal abdominal aorta, followed by the ascending thoracic aorta. Unlike coronary heart disease, the incidence of abdominal aortic aneurysm (AAA) in the United States and Europe has been increasing, and this increase may not be due to higher levels of screening for this condition alone. Aortic diameter is central to the diagnosis of aortic aneurysm. Furthermore, it was demonstrated that non-AAA patients with an enlarged diameter of the infrarenal aortic diameter are also at high risk for all-cause mortality. And aortic root dimension was associated with several coronary artery disease (CHD) risk factors and measures of subclinical disease and was predictive of incident congestive heart failure (CHF), stroke, cardiovascular disease (CVD) mortality, and all-cause mortality, but not of incident MI. Up to now, there are limited studies on the epidemiology of aortic diameter, especially in Chinese population.

Condition or disease Intervention/treatment
Vascular Disease Diabetes Hypertension Hyperlipidemia Other: No special interventioin

Detailed Description:
The purpose of this study was to analyze the size of the entire aorta at different anatomic levels in a large group of Chinese population with clinically evident arterial disease or cardiovascular risk factors to further explored the risk factors and potential alternative pathomechanisms for the development of aortic dilatation. Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels: (1) the annulus, (2) the mid-point of the sinuses of Valsalva, (3) the sinotubular junction, (4) the ascending aorta at the level of its largest diameter, (5) the transverse arch, (6) the descending aorta posterior to the left atrium, and (7) the abdominal aorta just distal to the origin of the renal arteries. The extension of dilation is defined as the number of dilated aortic segments. The relations among aortic dimensions and clinical characteristics will be assessed by multiple regression analysis. The current study was to determine the association of risk factors of CVD and atherosclerosis diseases with aortic dimension in Chinese patients with clinical event atherosclerotic disease or risk factors of atherosclerotic disease.

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Study Type : Observational
Estimated Enrollment : 2000 participants
Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
Official Title: Epidemiology of Aortic Dimensions in Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors
Study Start Date : January 2009
Estimated Primary Completion Date : December 2010
Estimated Study Completion Date : December 2015

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
atherosclerosis
Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors
Other: No special interventioin
Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels:





Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Chinese population with clinically evident arterial disease or cardiovascular risk factors
Criteria

Inclusion Criteria:

  • Patients aged 40 to 100 were referred to the hospital with a recent diagnosis of clinically evident arterial disease or a cardiovascular risk factor.

Exclusion Criteria:

  • Those with connective tissue disease, congenital heart disease, cardiomyopathy, congestive heart failure,rheumatic arthritis, secondary causes of hypertension, or active cancer.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00820378


Contacts
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Contact: Xiao-feng Chen, MD. 86-13656680890 zjxiaofengchen@hotmail.com

Locations
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China, Zhejiang
Second Affiliated Hospital of Zhejiang University College of Medicine Recruiting
Hangzhou, Zhejiang, China, 317000
Contact: Zhao-xia Pu    86-13989488402    zhaoxiapu@163.com   
Principal Investigator: Zhao-xia Pu, MD         
Taizhou Hospital, Wenzhou Medical College Recruiting
Taizhou, Zhejiang, China, 317000
Contact: Li-jiang Tang    86-13606655138    taizhoutang@hotmail.com   
Principal Investigator: Li-jiang Tang         
Sponsors and Collaborators
Zhejiang University
Taizhou Hospital
Investigators
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Study Chair: Jian-an Wang Second Affiliated Hospital, School of Medicine, Zhejiang University
Principal Investigator: Li-jiang Tang Taizhou Hospital, Wenzhou Medical College
Principal Investigator: Xiao-feng Chen Second Affiliated Hospital, School of Medicine, Zhejiang University
Principal Investigator: Zhao-xia Pu Second Affiliated Hospital, School of Medicine, Zhejiang University
Principal Investigator: Xian-fang Lin Taizhou Hospital, Wenzhou Medical College
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Responsible Party: Jian-an Wang/Prof., Second Affiliated Hospital, College of Medicine, Zhejiang University
ClinicalTrials.gov Identifier: NCT00820378    
Other Study ID Numbers: EPAD
First Posted: January 12, 2009    Key Record Dates
Last Update Posted: January 14, 2009
Last Verified: January 2009
Keywords provided by Zhejiang University:
Aortic dimension
Atherosclerosis
Vascular disease
Risk factors
Additional relevant MeSH terms:
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Vascular Diseases
Hyperlipidemias
Cardiovascular Diseases
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases