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Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration (FRET)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00809107
Recruitment Status : Completed
First Posted : December 17, 2008
Last Update Posted : February 19, 2009
Information provided by:
Universitair Ziekenhuis Brussel

Brief Summary:
The rational of the study is to assess the implantation, pregnancy and live birth rates after the transfer of frozen- thawed embryos in natural cycles with spontaneous Luteinizing Hormone (LH)/Progesterone rise or in natural cycles controlled by human chorionic gonadotropin (hCG) for final oocyte maturation and ovulation.

Condition or disease Intervention/treatment Phase
Infertility Drug: HCG Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 150 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cryopreserved-Thawed Embryo Transfer in Natural Cycle or in Natural Cycles Controlled by External Administration of hCG: a Prospective Randomized Study
Study Start Date : October 2006
Actual Primary Completion Date : July 2008
Actual Study Completion Date : January 2009

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1
Drug: HCG
Other Name: pregnyl

No Intervention: 2
LH pick

Primary Outcome Measures :
  1. Implantation rate [ Time Frame: 2 years ]

Secondary Outcome Measures :
  1. Ongoing pregnancy rate [ Time Frame: 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age <40
  • BMI:18-29Kg/m2
  • day 3 embryo transfers
  • previously IVF or ICSI

Exclusion Criteria:

  • irregular cycles
  • oocyte donation cycles

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00809107

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Centre of Reproductive Medicine
Brussel, Belgium, 1090
Sponsors and Collaborators
Universitair Ziekenhuis Brussel

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Responsible Party: Kyrou Dimitra, centre of reproductive medicine-UZ Identifier: NCT00809107     History of Changes
Other Study ID Numbers: TC3471
First Posted: December 17, 2008    Key Record Dates
Last Update Posted: February 19, 2009
Last Verified: February 2009
Keywords provided by Universitair Ziekenhuis Brussel:
natural cycle
spontaneous LH pic
Additional relevant MeSH terms:
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Genital Diseases, Male
Genital Diseases, Female