Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis in Intraocular Pressure (IOP) After Bevacizumab
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|ClinicalTrials.gov Identifier: NCT00804921|
Recruitment Status : Completed
First Posted : December 9, 2008
Last Update Posted : December 9, 2008
Purpose: To evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure (IOP) variations after intravitreal bevacizumab injection (IVBV).
Methods: 47 patients scheduled for IVBV (1.5 mg / 0.06 ml) will be randomly assigned to a pre-treatment 1 hour before IVBV with either 250 mg oral acetazolamide (DIA, 9 eyes), anterior chamber paracentesis immediate after IVBV (PAR, 15 eyes), topic brimonidine tartarate 1 hour before IVBV (BRI, 14 eyes), or no pre-treatment IBVB (CTR, 9 eyes). IOP will be measured 90 minutes before injection (baseline), just before injection, and at 3, 10, 20 and 30 minutes after the procedure.
|Condition or disease||Intervention/treatment||Phase|
|Macular Edema Diabetic Retinopathy Macular Degeneration||Drug: bevacizumab Procedure: anterior chamber paracentesis Drug: acetazolamide Drug: brimonidine||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Official Title:||Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab Injection: Preliminary Results|
- Intra-ocular pressure variation after intra-vitreous injection of bevacizumab
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00804921
|School of Medicine - Clinical Hospital|
|Ribeirao Preto, SP, Brazil, 14049-900|