Arterial Blood Pressure-complexity in Septic Patients
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|ClinicalTrials.gov Identifier: NCT00793078|
Recruitment Status : Suspended (Awaiting decision on financial support by Deutsche Forschungsgemeinschaft (DFG))
First Posted : November 19, 2008
Last Update Posted : March 1, 2011
Arterial blood pressure (ABP) is regulated by multiple, interconnected feedback loops resulting in a variable and complex time course. According to the "decomplexification theory of illness", disease is characterised by a loss or impaired function of feedback loops resulting in a decreased complexity of the ABP-time course and an impaired adaptability of the cardiovascular system.
Decomplexification of physiologic parameters has been shown to occur in coronary heart disease, Parkinson's and Hodgkin's disease, and in subarachnoid hemorrhage, but has not been evaluated in sepsis.
This study is intended to test the hypothesis that complexity of ABP
- is lower in cardiac surgery versus non-cardiac surgery septic patients,
- decreases as severity of sepsis increases to severe sepsis and septic shock,
- is associated with outcome three month after sepsis.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||72 participants|
|Observational Model:||Case Control|
|Official Title:||Investigation of Arterial Blood Pressure-complexity and Its Relation to Outcome in Comparison Between Cardiac Surgery Versus Non-cardiac Surgery Septic Patients|
|Study Start Date :||January 2009|
|Estimated Primary Completion Date :||December 2012|
|Estimated Study Completion Date :||December 2012|
- short form-36 [ Time Frame: 3 month after discharge ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00793078
|Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn|
|Bonn, Germany, 53105|
|Principal Investigator:||Martin Soehle, M.D., D.E.S.A., D. habil.||Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn|