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Effect of Exercise on the Disease Activity of Rheumatoid Arthritis (RA&Ex)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00792675
Recruitment Status : Completed
First Posted : November 18, 2008
Last Update Posted : November 18, 2008
Arthritis Foundation
UNMC and The Nebraska Medical Center, Research Support Fund
Information provided by:
University of Nebraska

Brief Summary:
The goal of this study was to evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis. It was hypothesized that persons would have less inflammation associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weighlifting. Immune parameters were measured to determine potential mechanisms responsible for changes in inflammation with exercise.

Condition or disease Intervention/treatment Phase
Rheumatoid Arthritis Other: Aerobic and resistance exercise training Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 55 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : January 2003
Actual Primary Completion Date : April 2006
Actual Study Completion Date : November 2007

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Exercise Other: Aerobic and resistance exercise training
Exercise was performed 3 times per week. It consisted of 30 minutes of treadmill exercise at approximately 85% of heartrate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.

Primary Outcome Measures :
  1. Swollen Joint Count [ Time Frame: 12 Weeks ]
  2. Tender Joint Count [ Time Frame: 12 Weeks ]

Secondary Outcome Measures :
  1. Pain (visual Analog Scale) [ Time Frame: 12 Weeks ]
  2. Modified-Health Assessment Questionnaire [ Time Frame: 12 Weeks ]
  3. Estimated Aerobic Capacity (VO2max) [ Time Frame: 12 weeks ]
  4. SF-36 [ Time Frame: 12 Weeks ]
  5. Patient Global Assessment [ Time Frame: 12 Weeks ]
  6. Practitioner Global Assessment [ Time Frame: 12 Weeks ]
  7. Timed-Stands Test [ Time Frame: 12 Weeks ]
  8. 50 Foot Walk Test [ Time Frame: 12 Weeks ]

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • a diagnosis of RA according to the ACR 1989 Criteria at least 6 months prior to enrollment in the study, but not longer than 12 years
  • age 19 to 65 years old
  • stable regimen of medication for 2 months with less than 10 mg/day of oral corticosteroids
  • currently exercise < 2x/week for less than 30 minutes at less than 60% of his/her age predicted maximum heart rate
  • Subjects must pass the Physical Activity Readiness Scale Questionnaire (PAR-Q)

Exclusion Criteria:

  • other serious health problems
  • intra-articular injection within 6 weeks
  • total joint replacement of the large joints
  • use of beta-blockers
  • inability to complete the submaximal exercise test

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00792675

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United States, Nebraska
Division of Physical Therapy Education Physical Activity Lab
Omaha, Nebraska, United States, 69189-4420
Sponsors and Collaborators
University of Nebraska
Arthritis Foundation
UNMC and The Nebraska Medical Center, Research Support Fund
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Responsible Party: Laura D. Bilek, PhD, PT, Division of Physical Therapy Education, UNMC Identifier: NCT00792675    
Other Study ID Numbers: 267-02-FB
First Posted: November 18, 2008    Key Record Dates
Last Update Posted: November 18, 2008
Last Verified: November 2008
Keywords provided by University of Nebraska:
disease activity
resistance training
Additional relevant MeSH terms:
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Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases