Prenatal Corticosteroids and Antioxidants in Preterm Infants (RESOX)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00791687|
Recruitment Status : Completed
First Posted : November 14, 2008
Last Update Posted : November 14, 2008
|Condition or disease|
This is an observational study recruiting extremely low gestational age neonates (<28 weeks gestation) whose mothers received or not full scheduled prenatal glucocorticosteroids. Healthy term newly born infants acted as controls.
At birth cord blood were drawn for the following analytical determinations: reduced and oxidized glutathione; malondialdehyde; superoxide dismutase; catalase; glutathione peroxidase; glutathione reductase; glutathione s-transferase. In addition, first urine voided was collected for ortho-tyrosine/phenylalanine and 8-hydroxy-2-oxo-deoxyguanosine/2-deoxyguanosine determination. Analytical data and clinical outcomes are compared.
|Study Type :||Observational|
|Actual Enrollment :||57 participants|
|Official Title:||Prenatal Corticosteroids Enhance the Antioxidant Defense System in Extremely Low Gestational Age Neonates|
|Study Start Date :||January 2003|
|Actual Primary Completion Date :||January 2005|
|Actual Study Completion Date :||January 2005|
Extremely low gestational age neonates (<28 weeks gestation) whose mothers received full course of betamethasone before delivery.
NON PRENATAL CORTICOSTEROIDS
Extremely low gestational age neonates (<28 weeks gestation) whose mothers did not receive full course of betamethasone before delivery.
- Evaluation of glutathione redox status in cord blood. [ Time Frame: at birth ]
- Evaluation of antioxidant activity. [ Time Frame: at birth ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00791687
|Division of Neonatology; University Hospital La Fe|
|Valencia, Spain, 46009|
|Principal Investigator:||MAXIMO VENTO, PHD, MD||Valencian Agency of Health|