Proportional Assist Ventilation vs Pressure Support Ventilation
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|ClinicalTrials.gov Identifier: NCT00790725|
Recruitment Status : Terminated (The patient population in RACU has changed significantly, we can not find potential subjects to recruit. The enrollment rate has reached zero.)
First Posted : November 13, 2008
Last Update Posted : April 25, 2012
In this study, we want to compare two different kinds of artificial ventilation to see if one encourages faster weaning from breathing support and if one provides better sleep quality. These artificial ventilation types are:
- Pressure support ventilation; the standard ventilation that we use for the patients in the Respiratory Acute Care Unit. Pressure support ventilation ventilators use constant air pressure to assist patients with their breathing.
- Proportional assist ventilation; a newer way of helping people with their breathing. The air pressure provided by proportional assist ventilation ventilators varies with the size of the breath that a person takes.
|Condition or disease||Intervention/treatment||Phase|
|Respiration, Artificial||Other: Proportional Assist Ventilation Other: Pressure Support Ventilation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Proportional Assist Ventilation vs. Pressure Support Ventilation in the Management of Patients Referred to a Respiratory Acute Care Unit|
|Study Start Date :||November 2008|
|Actual Primary Completion Date :||May 2010|
|Actual Study Completion Date :||May 2010|
Proportional Assist Ventilation will be used as a mechanical ventilation method for randomized patients in RACU
Other: Proportional Assist Ventilation
Proportional Assist Ventilation will be used to ventilate the patients.
Pressure Support Ventilation will be used as a mechanical ventilation method for randomized patients in RACU
Other: Pressure Support Ventilation
Pressure Support ventilation will be used to ventilate the patients.
- Length of time mechanically ventilated in the RACU [ Time Frame: 30 days ]
- Sleep quality [ Time Frame: 48 hours ]
- Inflammatory mediator levels [ Time Frame: 30 days ]
- Hospital mortality [ Time Frame: 30 days ]
- 60 day mortality [ Time Frame: 60 days ]
- 180 day mortality [ Time Frame: 180 days ]
- 365 day mortality [ Time Frame: 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00790725
|United States, Massachusetts|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Robert M Kacmarek, PhD||Massachusetts General Hospital|