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Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00790634
Recruitment Status : Unknown
Verified November 2008 by Sheba Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : November 13, 2008
Last Update Posted : November 13, 2008
University of Haifa
Israel Science Foundation
Information provided by:
Sheba Medical Center

Brief Summary:
The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive disorder, by examining performance on cognitive tasks involving cognitive flexibility, decision-making, and attentional bias.

Condition or disease
Parkinson's Disease Obsessive-Compulsive Disorder

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Characterizing Mechanisms of Fronto-Subcortical Dysfunction: A Comparison Between Parkinson's Disease and Obsessive-Compulsive Disorder
Study Start Date : December 2008
Estimated Primary Completion Date : December 2011
Estimated Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

Parkinson's Disease
Patients with idiopathic Parkinson's disease
Obsessive-compulsive disorder
Individuals with a diagnosis of obsessive-compulsive disorder
OCD controls
Healthy controls, matched in age and number to obsessive-compulsive group
PD controls
Healthy controls, matched in age and number to Parkinson's disease group

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 85 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
private and hospital-based clinics, healthy volunteers

Inclusion Criteria:

  • idiopathic PD or
  • OCD
  • for control group - age-matched to study groups

Exclusion Criteria:

  • psychotic symptoms (past or present)
  • head injury with loss of consciousness
  • other neurological conditions (excepting PD in PD group)
  • for OCD group - use of dopaminergic medications

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00790634

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Contact: Sharon Hassin, MD 97235305791
Contact: Sari Meril, M.Sc 972

Sponsors and Collaborators
Sheba Medical Center
University of Haifa
Israel Science Foundation
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Responsible Party: Dr. Sharon Hassin, principal investigator, Sheba Medical Center Identifier: NCT00790634    
Other Study ID Numbers: SHEBA-08-5473-SH-CTIL
First Posted: November 13, 2008    Key Record Dates
Last Update Posted: November 13, 2008
Last Verified: November 2008
Additional relevant MeSH terms:
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Parkinson Disease
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Personality Disorders
Mental Disorders
Anxiety Disorders