Sex and Obesity: Effects on Heart Failure Study
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| ClinicalTrials.gov Identifier: NCT00776035 |
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Recruitment Status :
Active, not recruiting
First Posted : October 20, 2008
Last Update Posted : June 6, 2018
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Sex has a major impact on myocardial metabolism and blood flow. In subjects without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow.
Obesity is a major risk factor for Heart Failure. In subjects without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men.
To measure blood flow and metabolism we will be using radioactive materials and a PET (positron emission Tomography)scan to study the metabolism of the heart.
Hypotheses: 1) Women with nonischemic heart failure will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with nonischemic heart failure 2) Patients with obesity-related HF have a myocardial metabolic profile that is similar to that of obese subjects without heart failure and different (higher FA metabolism) from that of nonobese Heart failure patients.
| Condition or disease | Intervention/treatment |
|---|---|
| Obesity Heart Failure | Procedure: PET (positron Emission Tomography) Procedure: Echocardiogram Procedure: VO2 peak test Procedure: Body composition Study Radiation: 15O water Radiation: 11C Acetate Radiation: 11C Palmitate Radiation: 11C Glucose |
| Study Type : | Observational |
| Estimated Enrollment : | 10 participants |
| Observational Model: | Other |
| Time Perspective: | Prospective |
| Official Title: | Sex and Obesity Effects on Myocardial Blood Flow and Metabolism |
| Study Start Date : | January 2008 |
| Estimated Primary Completion Date : | February 2019 |
| Estimated Study Completion Date : | February 2019 |
| Group/Cohort | Intervention/treatment |
|---|---|
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heart failure
Obesity related Heart failure population
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Procedure: PET (positron Emission Tomography)
this is a diagnostic scan that requires the injection of radioactive tracers into an IV placed in the arm.
Other Name: PET scan Procedure: Echocardiogram an ultrasound of the heart
Other Name: Echo Procedure: VO2 peak test walking on a treadmill during which you will breath in and out through a tube Procedure: Body composition Study a scan of your entire body measuring Body Mass Index, fat percentage etc...
Other Name: DEXA scan Radiation: 15O water radioactive tracer used to study blood flow during the PET scan Radiation: 11C Acetate radioactive tracer that helps study heart metabolism Radiation: 11C Palmitate radioactive tracer used to study fatty acid usage in the heart Radiation: 11C Glucose radioactive tracer usde to study glucose usage in the heart |
- Myocardial blood flow, glucose metabolism, oxygen metabolism, and fat metabolism [ Time Frame: the time frame of the study ]The heart uses sugars, fats, oxygen to make its energy for function.
Biospecimen Retention: Samples With DNA
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| Ages Eligible for Study: | 20 Years to 65 Years (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Inclusion Criteria: men and women
- Non Ischemic Heart failure, ejection fraction <40%, premenopausal, Obese(BMI >30),Lean, age 20-50, non diabetic
Exclusion Criteria:
- Pregnancy, lactating, actively losing weight, nonsedentary, greater than Class I hypertension,require alterations in heart medications, Diabetics.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00776035
| United States, Missouri | |
| Washington University School of Medicine | |
| Saint Louis, Missouri, United States, 63110 | |
| Principal Investigator: | Linda Peterson, MD | Washington University School of Medicine |
Publications:
| Responsible Party: | Washington University School of Medicine |
| ClinicalTrials.gov Identifier: | NCT00776035 History of Changes |
| Other Study ID Numbers: |
07-1128 |
| First Posted: | October 20, 2008 Key Record Dates |
| Last Update Posted: | June 6, 2018 |
| Last Verified: | June 2018 |
Keywords provided by Washington University School of Medicine:
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Obesity Heart Failure |
PET radiation metabolism |
Additional relevant MeSH terms:
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Obesity Heart Failure Overnutrition Nutrition Disorders Overweight |
Body Weight Signs and Symptoms Heart Diseases Cardiovascular Diseases |