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sgp130 in Chronic Human Liver Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00770198
Recruitment Status : Completed
First Posted : October 9, 2008
Last Update Posted : October 9, 2008
Information provided by:
Erasme University Hospital

Brief Summary:
Chronic liver disease are characterized by increased levels of plasma IL-6, but the bioactivity of this cytokine in this disease is not well known. IL-6 receptor complex is regulated by multiple receptors subunits: the soluble form of IL-6 Receptor enhance IL-6 signal by a process called trans-signaling on cells expressing few membrane IL-6 receptors. Soluble gp130 is the natural inhibitor of IL-6 trans-signaling. The aim of this study is to characterize circulating and liver levels of theses compounds of IL-6 receptor complex, to unravel the bioactivity of IL-6 in this disease.

Condition or disease
Alcoholic Liver Disease Chronic Hepatitis C Virus Infection

Detailed Description:
Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver IL-6R compounds mRNA levels.

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Study Type : Observational
Actual Enrollment : 129 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study of IL-6 Transsignaling in Chronic Human Liver Disease
Study Start Date : January 2005
Actual Primary Completion Date : January 2007
Actual Study Completion Date : October 2008

Resource links provided by the National Library of Medicine

alcoholic liver disease
alcoholic liver disease patients undergoing a transjugular liver biospy in our institution
chronic HCV hepatitis
chronic HCV hepatitis patients undergoing a transjugular liver biopsy in our institution

Biospecimen Retention:   Samples Without DNA
plasma, liver biopsies, and peripheral blood mononuclear cell culture medium.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients of Erasme University Hospital

Inclusion Criteria:

  • Alcohol excess intake and suspected liver disease
  • Alcohol excess intake and clinical liver cirrhosis
  • chronic hepatitis C virus infection and suspected liver disease
  • chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion Criteria:

  • other (superimposed) liver disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00770198

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Hopital Erasme - Dpt of Gastroenterology
Brussels, Belgium, 1070
Sponsors and Collaborators
Erasme University Hospital
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Principal Investigator: Arnaud Lemmers, MD Erasme Hospital, Gastroenterology Dpt
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Responsible Party: Olivier Le Moine, MD, PhD, Erasme University Hospital Identifier: NCT00770198    
Other Study ID Numbers: AL-gp130
First Posted: October 9, 2008    Key Record Dates
Last Update Posted: October 9, 2008
Last Verified: October 2008
Keywords provided by Erasme University Hospital:
Additional relevant MeSH terms:
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Hepatitis C
Hepatitis C, Chronic
Liver Diseases
Liver Diseases, Alcoholic
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Flaviviridae Infections
RNA Virus Infections
Hepatitis, Chronic
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders