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Stone Centre Urine and Serum Bank

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00759343
Recruitment Status : Unknown
Verified March 2016 by University of British Columbia.
Recruitment status was:  Active, not recruiting
First Posted : September 25, 2008
Last Update Posted : March 16, 2016
Information provided by (Responsible Party):
University of British Columbia

Brief Summary:


The purpose of the Stone Centre Serum and Urine Bank is to provide researchers with large numbers of serum and urine samples from kidney stone patients and controls for study of stone disease detection and treatment, and will take into account different genetic backgrounds, ages, and other patient factors to provide a broad sample size for the study of stone disease The Serum and Urine Bank will undoubtedly be an invaluable tool in the quest to understanding urinary stone disease.


The objective of this research is to identify protein species or other compounds responsible for or contributing to kidney stone initiation and propagation.

Condition or disease
Kidney Stones

  Show Detailed Description

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Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Case Control
Official Title: Stone Centre Urine and Serum Bank
Study Start Date : June 2008
Estimated Primary Completion Date : December 2018
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

Control Group

The control subjects of this study will be asked to undergo renal ultrasound examination, if available, or will be asked to complete a disease history form to determine the presence or lack of a kidney stone. Urine and serum will then be taken for storage until further analysis.

Controls will be asked to undergo a screening renal ultrasound to ensure they are stone free, this will take approximately 45 minutes. If the controls are asked to complete the history form, this will not take more than 20 minutes. They will also give a blood and urine sample during this time to bring the total extra time up to at most 60 minutes for controls."

Stone Group

The stone group will undergo standard diagnostic procedures for their condition and recovery process. Serum and urine for storage and analysis will be taken prior to stone treatment and 6 weeks following stone treatment. This will allow for the determination of differences in a stone patient's protein profile while they have their stone and after they are stone free. All patients will be required to have a stone patient metabolic evaluation which includes serum and urine testing. The analysis will focus on the serum and urine sample that they provide.

The stone patient will be asked to undergo one extra tube of blood during their preoperative assessment which should only add a few seconds to their visit.

Primary Outcome Measures :
  1. genetic factors in stone disease [ Time Frame: one time sample ]

Biospecimen Retention:   Samples With DNA

Urine and serum of stone-forming individuals and non-stone forming controls will be banked for analysis of protein biomarkers and predisposing factors. Ureteral stents removed from patients that would otherwise be discarded will be processed and stored to assess for bacterial and biofilm adherence.

Serum and Urine specimens will be collected, de-identified, and banked/retained.

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Accepts patients with stone disease and healthy volunteers as controls

Inclusion Criteria:

  • Controls: age > 19 and no history of kidney stone disease);
  • Study (Stone Patient): Age > 19, radiological evidence indicating presence of a current renal or ureteric stone.

Exclusion Criteria:

  • Pregnancy,
  • Positive Urine Culture,
  • Active cancer,
  • Recurrent urinary infections,
  • Gross hematuria,
  • Inability to provide informed consent,
  • Investigator's refusal to include,

    • Family history of stones,
    • History of stones

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00759343

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Canada, British Columbia
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
UBC Hospital
Vancouver, British Columbia, Canada
Sponsors and Collaborators
University of British Columbia
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Principal Investigator: Ben H. Chew, MD, FRCSC University of British Columbia
Study Director: Ryan Paterson, MD University of British Columbia
Study Director: Howard Fenster, MD University of British Columbia
Study Director: Caitlin Dobie University of British Columbia
Study Director: Dirk Lange, MD University of British Columbia
Study Director: Mark Nigro, MD University of British Columbia

Additional Information:
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Responsible Party: University of British Columbia Identifier: NCT00759343     History of Changes
Other Study ID Numbers: H06-00151
First Posted: September 25, 2008    Key Record Dates
Last Update Posted: March 16, 2016
Last Verified: March 2016

Keywords provided by University of British Columbia:
Kidney stones
urinary stone disease
urinary stones

Additional relevant MeSH terms:
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Kidney Calculi
Pathological Conditions, Anatomical
Kidney Diseases
Urologic Diseases
Urinary Calculi