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Effect of Stress on Heroin-Related Memory Retrieval

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00759005
Recruitment Status : Completed
First Posted : September 25, 2008
Last Update Posted : September 25, 2008
Information provided by:
National Institute on Drug Dependence, China

Brief Summary:
The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Condition or disease Intervention/treatment Phase
Heroin Dependence Learning and Memory Drug: propranolol and cortisol Not Applicable

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Study Type : Interventional  (Clinical Trial)
Study Start Date : March 2007
Actual Primary Completion Date : June 2008
Actual Study Completion Date : September 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory
Drug Information available for: Propranolol

Arm Intervention/treatment
Experimental: A, 4 Drug: propranolol and cortisol

Primary Outcome Measures :
  1. Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria:

  • current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00759005

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China, Beijing
National Institute on Drug Dependence
Beijing, Beijing, China, 100191
Sponsors and Collaborators
National Institute on Drug Dependence, China

Layout table for additonal information Identifier: NCT00759005     History of Changes
Other Study ID Numbers: NIDD
First Posted: September 25, 2008    Key Record Dates
Last Update Posted: September 25, 2008
Last Verified: September 2008

Additional relevant MeSH terms:
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Heroin Dependence
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Antihypertensive Agents
Vasodilator Agents