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What is the Prevalence of Methicillin-Resistant Staphylococcus Aureus in Skin and Soft Tissue Infections Presenting to the Emergency Departments of a Canadian Academic Health Care Center? (CA-MRSA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00736554
Recruitment Status : Completed
First Posted : August 18, 2008
Last Update Posted : January 5, 2011
Canadian Association of Emergency Physicians
Information provided by:
Lawson Health Research Institute

Brief Summary:
Staphylococcus aureus is the most common bacteria responsible for skin, bone, and muscle infections. Recent studies from the United States have suggested that a type of this bacterium called methicillin resistant S. aureus (MRSA) has become dramatically more common, especially the community strain. However, Canadian data is still largely lacking. This study aims to determine the prevalence of community acquired (CA) MRSA among patients presenting with skin and soft tissue infections to the Urgent Care Center and Emergency Departments in London, Ontario. This will be determined by taking swabs at enrollment from patient's noses, throats, and sites of infection. Patients will be asked to complete a health questionnaire with the goal of identifying risk factors associated with CA-MRSA. Through follow-up swabs of participants' noses and throats at one and three months, the effects of treatment on patient's carrying MRSA will be determined. Results may be used to form guidelines for empirical S aureus treatment in the region, reducing possible morbidity and mortality from delayed or suboptimal treatment of CA-MRSA infections. Improved understanding of risk factors associated with MRSA infection in a Canadian setting, may also change the practice of physicians considering empiric antibiotic therapy for skin and soft tissue infections.

Condition or disease
Bacterial Infections Gram-Positive Bacterial Infections Staphylococcal Infections

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Study Type : Observational
Actual Enrollment : 152 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prevalence of MRSA in Skin and Soft Tissue Infections in Two Ontario Emergency Departments.
Study Start Date : July 2008
Actual Primary Completion Date : September 2008
Actual Study Completion Date : November 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: MRSA

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Selection of Participants: The objective of this prospective study is to determine the prevalence of MRSA and community acquired MRSA (CA-MRSA) in adult patients (>17 yrs old) presenting with skin or soft tissue infections to the emergency departments (EDs) of an academic health care setting in London, Ontario.

Inclusion Criteria:

  • All adult patients (> 17 years) whose chief complaint is consistent with skin or soft tissue infection (cellulitis, necrotizing soft tissue infection, wound infection, ulcer, septic bursitis, abscess including furuncle/carbuncle/superficial skin abscess, paronychia, hordeolum, pilonidal abscess, acute lymphadenitis, pilonidal cyst without abscess, and impetigo).

Exclusion Criteria:

  • Patients will be excluded if they refuse to participate or written, informed consent is not obtained.
  • Additionally, patients with Bartholin cysts, odontogenic infections and perianal abscesses will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00736554

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Canada, Ontario
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Sponsors and Collaborators
Lawson Health Research Institute
Canadian Association of Emergency Physicians
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Principal Investigator: Christopher MB Fernandes, FRCP, FACEP, MD University of Western Ontario, Canada
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Responsible Party: Dr. Christopher Fernandes, London Health Sciences Centre Identifier: NCT00736554    
Other Study ID Numbers: R-08-173
13871E ( Other Identifier: REB )
First Posted: August 18, 2008    Key Record Dates
Last Update Posted: January 5, 2011
Last Verified: January 2011
Keywords provided by Lawson Health Research Institute:
Staphylococcus aureus
skin and soft tissue infections
emergency department
Additional relevant MeSH terms:
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Communicable Diseases
Bacterial Infections
Soft Tissue Infections
Staphylococcal Infections
Gram-Positive Bacterial Infections
Disease Attributes
Pathologic Processes