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Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00718406
Recruitment Status : Completed
First Posted : July 18, 2008
Last Update Posted : July 18, 2008
Information provided by:
Sahlgrenska University Hospital, Sweden

Brief Summary:
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine

Condition or disease Intervention/treatment Phase
Acute Coronary Syndromes Drug: Metoprolol Drug: metoprolol plus morphine Phase 4

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Study Type : Interventional  (Clinical Trial)

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chest Pain

Arm Intervention/treatment
Active Comparator: A
Drug: Metoprolol
Active Comparator: B
B=metoprolol plus morphine
Drug: metoprolol plus morphine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute chest pain
  • ECG-signs indicating myocardial ischemia

Exclusion Criteria:

  • Heart rate < 60 beats/min
  • Systolic blood pressure < 110 mmHg
  • High degree AV-block
  • Signs of obstructive pulmonary disease
  • Signs of pulmonary oedema
  • Unwillingness
  • Participation in other studies
  • Long delay between arrival of ambulance and randomisation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00718406

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Medical Institution, Dept of Molecular and Clinical Medicine, Sahlgrenska University Hospital
Göteborg, Sweden, SE-413 45
Sponsors and Collaborators
Sahlgrenska University Hospital, Sweden
Layout table for additonal information Identifier: NCT00718406    
Other Study ID Numbers: S203-02
First Posted: July 18, 2008    Key Record Dates
Last Update Posted: July 18, 2008
Last Verified: August 2002
Keywords provided by Sahlgrenska University Hospital, Sweden:
Acute coronary syndrome
Chest pain
Prehospital phase
Additional relevant MeSH terms:
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Acute Coronary Syndrome
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Antihypertensive Agents
Autonomic Agents
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action