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Constraint-Induced (CI) Movement Therapy for Progressive Multiple Sclerosis (MS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00695084
Recruitment Status : Completed
First Posted : June 11, 2008
Last Update Posted : June 11, 2008
Information provided by:
National Multiple Sclerosis Society

Brief Summary:
This trial will evaluate whether progressive multiple sclerosis associated with hemiparesis may benefit from Constraint-Induced Movement Therapy.

Condition or disease Intervention/treatment Phase
Multiple Sclerosis Behavioral: Constraint-Induced Movement Therapy Phase 1

Detailed Description:
Constraint-Induced Movement Therapy was developed to treat stroke hemiparesis. Due to the similarity between multiple sclerosis and stroke in terms of chronic motor deficit, this trial will attempt to determine whether multiple sclerosis may benefit similarly from Constraint-Induced Movement Therapy.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 7 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Constraint-Induced Movement Therapy Trial for Progressive Multiple Sclerosis
Study Start Date : March 2007
Actual Primary Completion Date : April 2008
Actual Study Completion Date : April 2008

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1
Treatment with Constraint-Induced Movement Therapy
Behavioral: Constraint-Induced Movement Therapy
Intensive practice with the hemiparetic arm for 30 contact hours
Other Name: CI Therapy

Primary Outcome Measures :
  1. Improvement on the Motor Activity Log [ Time Frame: One year ]

Secondary Outcome Measures :
  1. Improvement on the Wolf Motor Function Test [ Time Frame: Pre to post-treatment ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   21 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Chronic upper extremity motor deficit due to multiple sclerosis

Exclusion Criteria:

  • Relapse within 3 months of planned enrollment.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00695084

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United States, Alabama
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35249
Sponsors and Collaborators
National Multiple Sclerosis Society
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Principal Investigator: Victor W Mark, MD University of Alabama at Birmingham

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Responsible Party: Patricia O'Looney, National Multiple Sclerosis Society Identifier: NCT00695084    
Other Study ID Numbers: CIMSTrial
First Posted: June 11, 2008    Key Record Dates
Last Update Posted: June 11, 2008
Last Verified: June 2008
Keywords provided by National Multiple Sclerosis Society:
multiple sclerosis
Additional relevant MeSH terms:
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Multiple Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases