COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Acupuncture for Pain and Sleep Disturbance in Knee Osteoarthritis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00694447
Recruitment Status : Completed
First Posted : June 10, 2008
Last Update Posted : November 21, 2013
Southeast Center of Excellence in Geriatric Medicine
The John A. Hartford Foundation
Information provided by (Responsible Party):
Wei Huang MD, PhD, Emory University

Brief Summary:

The hypotheses of this study are: In the older population with knee OA,

  • When acupoints are chosen for both sleep and pain, there are additive effects on sleep improvement and pain relief (i.e. no interaction).
  • Main effects of acupuncture on sleep improvement and pain relief are anticipated when acupoints are separately targeted for sleep and for pain, respectively.

Condition or disease Intervention/treatment Phase
Sleep Pain Procedure: Acupuncture Not Applicable

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Official Title: Exploring Outcomes and Mechanisms of Acupuncture in Treating Pain and Sleep Disturbance in Knee Osteoarthritis
Study Start Date : February 2007
Actual Primary Completion Date : April 2008

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Real acupuncture
Real acupuncture
Procedure: Acupuncture
Sham Comparator: Sham acupuncture
Sham acupuncture
Procedure: Acupuncture

Primary Outcome Measures :
  1. Sleep disturbances as recorded by wrist actigraph, including sleep duration and sleep efficiency. Pain as measured by 0-10 VAS and WOMAC pain scores. [ Time Frame: at least 3 months ]

Secondary Outcome Measures :
  1. WOMAC disability scores, IDEEA gait patterns and activity levels, medication type and amount consumed, side effects, and medical care utilization. [ Time Frame: at least 3 months ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   55 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Patients with knee osteoarthritis, diagnosed by the ACR clinical diagnosis criteria for idiopathic OA, with at least Kellgren and Lawrence grading II and above. AND,
  2. Present with knee pain at least half of the time. AND,
  3. Complain of sleep disturbances associated with knee OA, with Pittsburgh Sleep Quality Index > 5 [36].

Exclusion Criteria:

  1. Patients with diagnosis of obstructive sleep apnea (OSA). OR,
  2. Patients with dense hemiplegia secondary to cerebrovascular accident. OR,
  3. NYHA Class III - patients with heart failure condition limited by minimal activity. OR,
  4. Severe COPD with shortness of breath at minimal exertion. OR,
  5. Peripheral vascular disease with severe claudication. OR,
  6. Dementia with Mini Mental Status Exam score of 20 or less. OR,
  7. Patients who received knee intra-articular corticosteroid injection within 4 weeks prior to the study or who received acupuncture treatment within 6 months. OR,
  8. Unwilling to come off narcotic pain medication. OR,
  9. History of bleeding diathesis or currently on anticoagulation. OR,
  10. Patients currently engaged in medical legal cases related to OA or disability.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00694447

Layout table for location information
United States, Georgia
Wesley Woods Geriatric Hospital
Atlanta, Georgia, United States, 30329
Sponsors and Collaborators
Emory University
Southeast Center of Excellence in Geriatric Medicine
The John A. Hartford Foundation
Layout table for investigator information
Principal Investigator: Wei Huang, MD, PhD Emory University

Additional Information:
Layout table for additonal information
Responsible Party: Wei Huang MD, PhD, Principal Investigator, Emory University Identifier: NCT00694447    
Other Study ID Numbers: IRB00000143
Grant #97333-G
First Posted: June 10, 2008    Key Record Dates
Last Update Posted: November 21, 2013
Last Verified: November 2013
Additional relevant MeSH terms:
Layout table for MeSH terms
Osteoarthritis, Knee
Sleep Wake Disorders
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Nervous System Diseases
Mental Disorders
Neurologic Manifestations
Signs and Symptoms