The Effect of Simvastatin on Desensitization of Panel-Positive Kidney Transplant Candidates
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|ClinicalTrials.gov Identifier: NCT00693576|
Recruitment Status : Completed
First Posted : June 9, 2008
Last Update Posted : June 9, 2008
|Condition or disease||Intervention/treatment||Phase|
|Renal Transplantation||Drug: simvastatin||Phase 2 Phase 3|
The presence of panel reactive antibodies (PRAs) in the sera of renal transplant candidates is associated with hyperacute or delayed humoral immune responses against the graft after transplantation .
In addition, these sensitized patients wait for a long time to find a cross-match negative kidney for renal transplantation . As a result, some modalities have been used for desensitization including plasmapheresis and intravenous immunoglobulin (IVIG) in combination with immunosuppressive drugs .
However, recently, the use of statins such as simvastatin, pravastatin and etc. has been proposed to be safer and more effective for desensitization .
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||82 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Simvastatin on Desensitization of Panel-Positive Kidney Transplant Candidates|
|Study Start Date :||April 2007|
|Actual Primary Completion Date :||May 2008|
|Actual Study Completion Date :||May 2008|
patients who will take simvastatin 20 mg daily
20 mg simvastatin daily
- effect of simvastatin on panel reactive antibody [ Time Frame: 12 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00693576
|Iran, Islamic Republic of|
|Shiraz University of Medical Sciences|
|Shiraz, Fars, Iran, Islamic Republic of, 71937-11351|
|Study Director:||jamshid roozbeh, associate professor||shiraz university of medical science|
|Principal Investigator:||azar Sattarinezhad, internal medicine resident||shiraz university of medical science,internal medicine department|
|Principal Investigator:||mohammad mahdi sagheb, assistant professor||Shiraz University of Medical Sciences|