Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu

Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00690547
Recruitment Status : Unknown
Verified November 2009 by German Research Foundation.
Recruitment status was:  Active, not recruiting
First Posted : June 4, 2008
Last Update Posted : November 30, 2009
Sponsor:
Information provided by:
German Research Foundation

Brief Summary:
Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

Condition or disease Intervention/treatment
Muscle Quadriceps Femoris Healthy Other: muscle activation

Detailed Description:
The research proposal is resubmitted with no amendments made regarding content.

Layout table for study information
Study Type : Observational
Estimated Enrollment : 60 participants
Time Perspective: Prospective
Official Title: Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.
Study Start Date : October 2008
Estimated Primary Completion Date : October 2010
Estimated Study Completion Date : October 2010

Group/Cohort Intervention/treatment
Test Group Other: muscle activation
activation of the muscle quadriceps femoris




Primary Outcome Measures :
  1. Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend). [ Time Frame: 12 months ]

Secondary Outcome Measures :
  1. Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation [ Time Frame: 12 months ]
  2. Correlation between typ of muscle fiber and force enhancement in vivo [ Time Frame: 12 months ]
  3. Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength [ Time Frame: 12 months ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
males without previous muscular or neurophysiological diseases at an age between 20 and 40 years
Criteria

Inclusion Criteria:

  • Males without previous muscular or neurophysiological diseases
  • Age between 20 and 40 years

Exclusion Criteria:

  • Previous muscular or neurophysiological diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00690547


Locations
Layout table for location information
Germany
Technical University of Munich, Department of Biomechanics in Sports
Munich, Germany, 80809
Sponsors and Collaborators
German Research Foundation
Investigators
Layout table for investigator information
Principal Investigator: Ansgar Schmirtz, Prof. Dr. Technical University of Munich, Department of Biomechanics in Sports

Layout table for additonal information
Responsible Party: Prof. Dr. Ansgar Schwirtz, Technical University of Munich, Department of Biomechanics in Sports
ClinicalTrials.gov Identifier: NCT00690547     History of Changes
Other Study ID Numbers: DFG27112007
First Posted: June 4, 2008    Key Record Dates
Last Update Posted: November 30, 2009
Last Verified: November 2009

Keywords provided by German Research Foundation:
Functionality
Deliberately
Activated
Quadriceps
Femoris
During
After
Active
Extension