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Ultrasound Guided Embryo Transfer: Abdominal Versus Transvaginal, a RCT

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00682071
Recruitment Status : Completed
First Posted : May 22, 2008
Last Update Posted : October 5, 2015
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
Ultrasound (US) guided embryo transfer (ET) appears to improve pregnancy outcomes in IVF-ET. Most reports are done using a transabdominal (TAS) approach, in contrast to a transvaginal ultrasound (TVS) which does not require a full bladder. We sought to determine if either approach was better with respect to clinical outcomes.

Condition or disease
Infertility in Vitro Fertilization

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Study Type : Observational
Actual Enrollment : 224 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Abdominal Versus Transvaginal Ultrasound Guided Embryo Transfer: Results of a Randomized Clinical Trial
Study Start Date : August 2003
Actual Primary Completion Date : June 2007
Actual Study Completion Date : June 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Ultrasound

transabdominal ultrasound (TAS) guided embryo transfer
transvaginal ultrasound (TVS) guided embryo transfer

Primary Outcome Measures :
  1. pregnancy rates for TAS and TVS ultrasound-guided ET groups [ Time Frame: August 2003 to June 2007 ]

Secondary Outcome Measures :
  1. Length of time required for embryo transfer [ Time Frame: August 2003 to June 2007 ]
  2. differences between transferring physicians [ Time Frame: August 2003 to June 2007 ]
  3. multiple pregnancies [ Time Frame: August 2003 to June 2007 ]
  4. ectopic pregnancy rates [ Time Frame: August 2003 to June 2007 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients undergoing assisted reproductive cycles at the University of Wisconsin REI Program

Inclusion Criteria:

- All patients undergoing assisted reproductive cycles including autologous IVF, oocyte donation, and frozen embryo transfer (FET) cycles

Exclusion Criteria:

- Cases of severe ovarian hyper-stimulation requiring embryo cryopreservation and gestational surrogate cycles

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00682071

Sponsors and Collaborators
University of Wisconsin, Madison
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Principal Investigator: Steven R Lindheim, MD, MMM Fertility Specialists Medical Group

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Responsible Party: University of Wisconsin, Madison Identifier: NCT00682071     History of Changes
Other Study ID Numbers: 2003-311
IRB# 2003-311 (UW)
HSC# 2003-311 (UW)
Grant: OB/GYN R&D
Funding # 133-FZ71
First Posted: May 22, 2008    Key Record Dates
Last Update Posted: October 5, 2015
Last Verified: May 2008

Keywords provided by University of Wisconsin, Madison:
embryo transfer
in-vitro fertilization

Additional relevant MeSH terms:
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Genital Diseases, Male
Genital Diseases, Female