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Pleural Effusion Following Cardiac Surgery: Prevalence, Risk Factors and Clinical Features

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00665015
Recruitment Status : Completed
First Posted : April 23, 2008
Last Update Posted : April 23, 2008
Information provided by:
Laval University

Brief Summary:
Pleural effusion is a common complication of cardiac surgery. The aim of this study was to determine the prevalence, characteristics and determinants of clinically significant pleural effusions, defined as those requiring therapeutic pleural drainage.

Condition or disease
Pleural Effusion Coronary Artery Bypass

Detailed Description:

This was a retrospective cohort study of prevalence and characteristics of patients who had a pleural effusion after coronary artery bypass graft, valve replacement or both procedures.

Information was collected on all consecutive patients who underwent CABG surgery and/or valve replacement between January 1, 2004 and December 31, 2005. Demographic information, anthropometric parameters, cardiac and renal function assessments, and comorbid conditions were retrieved from medical files. We also collected data on the type of procedure, whether it was elective or urgent, the number and origin of the grafts, the duration of surgery and of cardiopulmonary bypass and the postoperative complications, including pleural effusions. Clinical presentation and evolution of the effusions as well as pleural fluid characteristics were also studied.

Patients were considered to have a clinically significant pleural effusion when they met at least one of the following criteria: need for thoracentesis, a pleural drainage tube or a hospital readmission due to a pleural effusion that occurred within one year of surgery.

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Study Type : Observational
Actual Enrollment : 2892 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Pleural Effusions Following Cardiac Surgery: Prevalence, Risk Factors and Clinical Features.
Study Start Date : January 2004
Actual Primary Completion Date : December 2005
Actual Study Completion Date : October 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Surgery

Primary Outcome Measures :
  1. Pleural effusion requiring therapeutic drainage [ Time Frame: within the first 12 months after surgery ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing coronary artery bypass grafting surgery, heart valve replacement surgery or both procedures.

Inclusion Criteria:

  • Coronary artery bypass grafting (CABG)
  • Valve replacement
  • Combined CABG and valve replacement
  • between January 1st, 2004 and December 31st, 2005

Exclusion Criteria:

  • Previous CABG
  • Pulmonary and/or aortic artery surgery
  • Heart or lung transplant
  • Pleural effusion present at the time of surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00665015

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Canada, Quebec
Unité de Recherche en Pneumologie, Hôpital Laval
Québec, Quebec, Canada, G1V4G5
Sponsors and Collaborators
Laval University
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Principal Investigator: Louis-Philippe Boulet, MD, FRCP(C) Unité de Recherche en Pneumologie, Hôpital Laval
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Louis-Philippe Boulet, Respirologist, Unité de Recherche en Pneumologie, Hôpital Laval Identifier: NCT00665015    
Other Study ID Numbers: PEFCS-summer 07
First Posted: April 23, 2008    Key Record Dates
Last Update Posted: April 23, 2008
Last Verified: April 2008
Keywords provided by Laval University:
pleural effusion
coronary artery bypass
heart valve replacement
Additional relevant MeSH terms:
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Pleural Effusion
Pleural Diseases
Respiratory Tract Diseases