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Effectiveness of a Femoral Block Following Total Knee Arthroplasty (TKA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00659087
Recruitment Status : Completed
First Posted : April 16, 2008
Last Update Posted : August 3, 2016
Information provided by (Responsible Party):
Tsui, Ban / Johnston DWC, Edmonton Civic Employees Research Fund

Brief Summary:

Hospital stays after total joint replacement surgery have been getting shorter over the past 10 years. This is mostly due to new ways to manage pain and early rehabilitation. To be able to go home safely soon after surgery, patients need to:

  • 1) have adequate pain control
  • 2) be able to move through activities of daily living on their own (using aids)

Femoral nerve block, in combination with pain medications, is one of the new treatment strategies that are currently being used at other hospitals in Canada, the United States and the United Kingdom. Nerve blocks involve a needle filled with local anesthetic into the nerve that allows the feeling of pain around the knee. With good pain management, patients will be able to more quickly bend their knee and regain the ability to walk with aids and move from sitting and lying positions to standing and walking. Once they can do these activities with adequate pain control, they can be discharged from hospital to continue recovery at home. The purpose of this study is to examine a new way of managing postoperative pain and encourage early knee flexion and mobility, while maintaining pain control for patients after total knee replacement. We believe that patients who receive the nerve block in addition to the regular pain medication will have more knee flexion at discharge and experience less pain than patients who only receive usual pain medications.

Condition or disease Intervention/treatment Phase
Total Knee Arthroplasty Procedure: Femoral Block Other: Usual Care Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Pilot Study of the Feasibility of Early Discharge After Total Knee Arthroplasty Using a Femoral Nerve Block
Study Start Date : April 2008
Actual Primary Completion Date : October 2009
Actual Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Knee Replacement

Arm Intervention/treatment
Experimental: Femoral Block
Those receiving femoral block in addition to usual pain management
Procedure: Femoral Block
Those receiving femoral block postoperatively

Active Comparator: Usual Care
Those receiving only usual pain management without a femoral block
Other: Usual Care
Those receiving only usual pain management postoperatively

Primary Outcome Measures :
  1. knee flexion [ Time Frame: at hospital discharge or day 4 postoperatively, whichever is earlier ]

Secondary Outcome Measures :
  1. pain [ Time Frame: daily in hospital, 2 weeks, 6 weeks, 12 weeks ]
  2. length of hospital stay [ Time Frame: during hospitalization ]
  3. nausea/vomiting [ Time Frame: during hospitalization ]
  4. participation in rehabilitation [ Time Frame: day of surgery ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Undergoing primary total knee arthroplasty
  • English-speaking
  • Preoperative knee ROM > 90 degrees
  • Body Mass Index < 40

Exclusion Criteria:

  • Regular preoperative opioid use
  • Hepatic insufficiency
  • Any contra-indications to receiving a femoral block

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00659087

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Canada, Alberta
University of Alberta Hospitals
Edmonton, Alberta, Canada, T6G 2B7
Sponsors and Collaborators
Edmonton Civic Employees Research Fund

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Responsible Party: Tsui, Ban / Johnston DWC, Pediatric and Adult Anesthesiologist, Associate Professor/Director of Clinical Research, Stollery Children's Hospital/University of Alberta Hospital, Edmonton Civic Employees Research Fund Identifier: NCT00659087    
Other Study ID Numbers: J-3224
First Posted: April 16, 2008    Key Record Dates
Last Update Posted: August 3, 2016
Last Verified: August 2016
Keywords provided by Tsui, Ban / Johnston DWC, Edmonton Civic Employees Research Fund:
Total Knee
Range of Motion