Bethaherpesviruses in Children Who Are Immune Suppressed
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|ClinicalTrials.gov Identifier: NCT00641121|
Recruitment Status : Completed
First Posted : March 21, 2008
Last Update Posted : January 12, 2018
Unexplained fever in children with cancer is a common occurrence, often requiring hospital admission for evaluation and treatment with intravenous antibiotics. While empiric use of intravenous antibiotics is the norm in this population, between 48-70% of febrile and neutropenic episodes remain without an identifiable source. An understudied area is the potential role of betaherpesvirus infections in such febrile episodes. These viruses are significant pathogens in patients who become immunocompromised in conjunction with organ transplantation or acquired immune deficiency syndrome (AIDS). It is possible that they are similarly pathogenic in children who become immunocompromised due to cancer chemotherapy.
Thus, we will investigate the association between the betaherpesviruses and fever in children with cancer. The betaherpesviruses include cytomegalovirus (CMV), human herpesvirus 6A (HHV-6A), human herpesvirus 6B (HHV-6B), and human herpesvirus 7 (HHV-7). These viruses are grouped based on shared biological and genetic properties. Each is commonly acquired in childhood, persists in the human host, and can reactivate. Reactivation occurs intermittently throughout life in healthy individuals and is seldom associated with disease. Immune suppression is associated with a higher likelihood of reactivation and clinical disease. Latency of these viruses involves highly regulated processes that result in the viruses evading destruction and persisting within the host. Should balance be disrupted, as with cancer and anticancer therapy altering the normal host state, the environment may become favorable for betaherpesvirus reactivation, leading to disease and further alterations of the immune system.
|Condition or disease|
|Immune Suppressed Children|
|Study Type :||Observational|
|Actual Enrollment :||80 participants|
|Official Title:||Bethaherpesviruses in Children Who Are Immune Suppressed|
|Study Start Date :||November 2005|
|Actual Primary Completion Date :||November 2015|
|Actual Study Completion Date :||November 2015|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00641121
|United States, Ohio|
|Cleveland, Ohio, United States, 44195|
|Principal Investigator:||Johanna Goldfarb, MD||The Cleveland Clinic|