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A Randomised Comparison on the Dose Requirement Between, Levobupivacaine, Ropivacaine and Bupivacaine in Intrathecal Anaesthesia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00636974
Recruitment Status : Completed
First Posted : March 17, 2008
Last Update Posted : October 23, 2013
Information provided by:
Hospital Authority, Hong Kong

Brief Summary:
To determine and compare the effective intrathecal dose of levobupivacaine, ropivacaine and bupivacaine for 50% of patients in lower limb surgery

Condition or disease Intervention/treatment Phase
Anesthesia, Conduction Surgery Procedure: Combined spinal epidural anaesthesia Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 75 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Minimum Local Anaesthetic Dose for Intrathecal Anaesthesia: a Randomised Comparison Between Levobupivacaine, Ropivacaine and Bupivacaine
Study Start Date : January 2006
Actual Study Completion Date : July 2008

Primary Outcome Measures :
  1. Sensory block at 12th thoracic dermatome or above and successful conduct of the lower limb surgery up to 50 minutes after the intrathecal injection of the study drug [ Time Frame: 50 minutes after the intrathecal injection of the study drug ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • body weight=40-90kg,
  • height higher than 145cm

Exclusion Criteria:

  • Known hypersensitivity to amide local anaesthetics,
  • patients who do not understand English and Chinese,
  • Body mass index higher than 35 kg per sq metre

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00636974

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Kwong Wah Hospital
Hong Kong, China
Sponsors and Collaborators
Hospital Authority, Hong Kong
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Principal Investigator: Ying Yin Lee, Dr Department of Anaesthesiology, Kwong Wah Hospital

Additional Information:
Layout table for additonal information Identifier: NCT00636974    
Other Study ID Numbers: KW/FR/05-025
First Posted: March 17, 2008    Key Record Dates
Last Update Posted: October 23, 2013
Last Verified: October 2013
Keywords provided by Hospital Authority, Hong Kong:
Patients who are going to have regional anaesthesia for lower limbs surgery.
Leg Surgery.
Additional relevant MeSH terms:
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Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Local
Sensory System Agents
Peripheral Nervous System Agents