Effects of Head Elevation on Intracranial Pressure in Children
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ClinicalTrials.gov Identifier: NCT00636376 |
Recruitment Status :
Completed
First Posted : March 14, 2008
Last Update Posted : October 21, 2008
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Condition or disease | Intervention/treatment | Phase |
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Head Injury | Procedure: Place HOB in alternate positions from 0-50 degrees. | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 18 participants |
Allocation: | Non-Randomized |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Effect of Head Elevation on Intracranial Pressure and Cerebral Venous Outflow in Children |
Study Start Date : | January 2002 |
Actual Primary Completion Date : | October 2008 |
Actual Study Completion Date : | October 2008 |

Arm | Intervention/treatment |
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Experimental: 1
Single arm--no randomization. All subjects enrolled will have vitals collected and three ultrasounds at different levels of head of the bed elevations.
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Procedure: Place HOB in alternate positions from 0-50 degrees.
Patients will receive an US while the HOB(Elevation of the head of bed) is 30 degrees(baseline) then they will increase the angle to 40 degrees, then 50 degrees. Another US will be done then in 20, 10, and o degree angles. Then another US will be done
Other Names:
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- ICP will be reduced with improvement in cerebral venous outflow which is dependent on intravascular volume status and intrathoracic pressure and each will have their own optimal head position. [ Time Frame: As long as ICP is being monitored. ]

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Ages Eligible for Study: | up to 18 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Neonates, children, and adolescents
- Intracranial pressure monitor in place
Exclusion Criteria:
- Severe multiorgan system failure
- Hemodynamic instability sufficient to preclude changes in head position

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00636376
United States, Pennsylvania | |
The Children's Hospital of Philadelphia | |
Philadelphia, Pennsylvania, United States, 19104 |
Principal Investigator: | Jimmy Huh, MD | Children's Hospital of Philadelphia |
Responsible Party: | Jimmy Huh, MD, The Children's Hospital of Philadelphia |
ClinicalTrials.gov Identifier: | NCT00636376 |
Other Study ID Numbers: |
2002-1-2721 |
First Posted: | March 14, 2008 Key Record Dates |
Last Update Posted: | October 21, 2008 |
Last Verified: | October 2008 |
elevated intracranial pressure inadequate cerebral perfusion secondary brain damage |
Craniocerebral Trauma Trauma, Nervous System Nervous System Diseases Wounds and Injuries |