Efficacy of Vitamin C Injection on Fatigue in Workers After Work
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ClinicalTrials.gov Identifier: NCT00633581 |
Recruitment Status :
Completed
First Posted : March 12, 2008
Last Update Posted : April 10, 2009
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Condition or disease | Intervention/treatment | Phase |
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Fatigue | Dietary Supplement: Ascorbic acid (Vitamin C) Dietary Supplement: Normal saline | Phase 2 Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 150 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Triple (Participant, Care Provider, Investigator) |
Primary Purpose: | Supportive Care |
Official Title: | Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial |
Study Start Date : | March 2008 |
Actual Primary Completion Date : | May 2008 |
Actual Study Completion Date : | May 2008 |

Arm | Intervention/treatment |
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Experimental: 1
Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.
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Dietary Supplement: Ascorbic acid (Vitamin C)
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
Other Names:
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Placebo Comparator: 2
Intravenous injections of 120ml of normal saline over 30 minutes.
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Dietary Supplement: Normal saline
Single intravenous injection of 120ml of normal saline over 30 minutes |
- Degree of fatigue at the point of time with visual analogue scale from 0 to 10 [ Time Frame: Before intravenous vitamin C injection and right after completing injections, and one day later ]
- Reactive oxygen species [ Time Frame: Before intravenous vitamin C injections, right after completing injections, and one day later ]
- Plasma vitamin C level [ Time Frame: Before intravenous vitamin C injections and right after completing injections ]

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Ages Eligible for Study: | 20 Years to 49 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Company workers working at least 5 days a week from morning to evening
- Volunteers who provided written informed consent
Exclusion Criteria:
- Acute illness
- Chronic disease such as diabetes, hypertension, liver disease, or renal disease
- Previous history of renal stone or gout
- Pregnant or lactating women
- Hypersensitivity to vitamins or intravenous injections
- History of vitamin supplements orally or parenterally within 2 days

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00633581
Korea, Republic of | |
DongGuk University International Hospital | |
Goyang-si, Gyeonggi-do, Korea, Republic of, 410-773 |
Principal Investigator: | Chang H Yeom, MD, PhD | KwanDong University Myungji Hospital |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | ChangHwan Yeom, Kwandong University College of Medicine Myungji Hospital |
ClinicalTrials.gov Identifier: | NCT00633581 |
Other Study ID Numbers: |
DUIH 2008-1-1 |
First Posted: | March 12, 2008 Key Record Dates |
Last Update Posted: | April 10, 2009 |
Last Verified: | April 2009 |
fatigue ascorbic acid oxidative stress |
Fatigue Ascorbic Acid Vitamins Micronutrients Nutrients |
Growth Substances Physiological Effects of Drugs Antioxidants Molecular Mechanisms of Pharmacological Action Protective Agents |